Mechanics, Structure and Function of Biopolymer Condensates

被引：29

作者：

Bergeron-Sandoval, Louis-Philippe ^{[1
]}

Michnick, Stephen W. ^{[1
,2
]}

机构：

[1] Univ Montreal, Dept Biochem, CP 6128,Succursale Ctr Vile, Montreal, PQ H3C 3J7, Canada

[2] Univ Montreal, Ctr Robert Cedergren, Bioinformat & Genom, CP 6128,Succursale Ctr Vile, Montreal, PQ H3C 3J7, Canada

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2018年 / 430卷 / 23期

基金：

加拿大健康研究院;

关键词：

phase separation; biopolymer condensates; viscoelastic properties; surface interface energy; mechanical potential; PHASE-SEPARATION; VISCOELASTIC PROPERTIES; P GRANULES; PROTEIN; DROPLETS; BEHAVIOR;

D O I：

10.1016/j.jmb.2018.06.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The spontaneous nature of biopolymer phase separation in cells entails that the resulting condensates can be thermodynamic machines, which, in the process of condensing, can take on distinct forms themselves and deform neighboring cellular structures. We introduce here general notions of material and mechanical properties of protein condensates with an emphasis on how molecular arrangements and intermolecular interaction within condensates determine their ability to do work on their surroundings. We further propose functional implications of these concepts to cellular and subcellular morphology and biogenesis. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：4754 / 4761

页数：8

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