The role of calcium channel blockers and resveratrol in the prevention of paraquat-induced parkinsonism in Drosophila melanogaster: a locomotor analysis

被引：21

作者：

Bagatini, Pamela Brambilla ^{[1
]}

Saur, Lisiani ^{[1
]}

Rodrigues, Mariana Freitas ^{[1
]}

Bernardino, Guilherme Cardoso ^{[1
]}

Paim, Mariana Fontoura ^{[1
]}

Coelho, Guilherme Peres ^{[1
]}

da Silva, Daniele Vieira ^{[1
]}

de Oliveira, Raquel Mattos ^{[1
]}

Schirmer, Helena ^{[3
,4
]}

Souto, Andre Arigony ^{[3
]}

Moreira Roca Vianna, Monica Ryff ^{[2
]}

Xavier, Leder Leal ^{[1
]}

机构：

[1] Pontificia Univ Catolica Rio Grande Sul PUCRS, Lab Biol Celular & Tecidual, Dept Ciencias Morfofisiol, Fac Biociencias, BR-90619900 Porto Alegre, RS, Brazil

[2] Pontificia Univ Catolica Rio Grande do Sul, Lab Biol & Desenvolvimento Sistema Nervoso, Dept Ciencias Morfofisiol, Fac Biociencias, BR-90619900 Porto Alegre, RS, Brazil

[3] Pontificia Univ Catolica Rio Grande do Sul, Lab Quim Prod Nat, Dept Quim Pura, Fac Quim, BR-90619900 Porto Alegre, RS, Brazil

[4] Univ Feevale, Novo Hamburgo, RS, Brazil

来源：

INVERTEBRATE NEUROSCIENCE | 2011年 / 11卷 / 01期

关键词：

Dihydropyridines; Resveratrol; Drosophila melanogaster; Paraquat; Parkinson's disease; Voltage-dependent calcium channels; RAT MODEL; LIFE-SPAN; SUBSTANTIA-NIGRA; OXIDATIVE DAMAGE; STRIATAL LEVEL; DRUG DISCOVERY; DISEASE; NEURONS; NEURODEGENERATION; ANTAGONISTS;

D O I：

10.1007/s10158-011-0116-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Studies have suggested that neuronal loss in Parkinson's disease (PD) could be related to the pacemaker activity of the substantia nigra pars compacta generated by L-type Ca(v) 1.3 calcium channels, which progressively substitute voltage-dependent sodium channels in this region during aging. Besides this mechanism, which leads to increases in intracellular calcium, other factors are also known to play a role in dopaminergic cell death due to overproduction of reactive oxygen species. Thus, dihydropyridines, a class of calcium channel blockers, and resveratrol, a polyphenol that presents antioxidant properties, may represent therapeutic alternatives for the prevention of PD. In the present study, we tested the effects of the dihydropyridines, isradipine, nifedipine, and nimodipine and of resveratrol upon locomotor behavior in Drosophila melanogaster. As previously described, paraquat induced parkinsonian-like motor deficits. Moreover, none of the drugs tested were able to prevent the motor deficits produced by paraquat. Additionally, isradipine, nifedipine, resveratrol, and ethanol (vehicle), when used in isolation, induced motor deficits in flies. This study is the first demonstration that dyhidropyridines and resveratrol are unable to reverse the locomotor impairments induced by paraquat in Drosophila melanogaster.

引用

页码：43 / 51

页数：9

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