Enantioseparation by chromatographic and electromigration techniques using ligand-exchange as chiral separation principle

被引：63

作者：

Schmid, Martin G. ^{[1
]}

Guebitz, Gerald ^{[1
]}

机构：

[1] Karl Franzens Univ Graz, Inst Pharmaceut Sci, Dept Pharmaceut Chem, A-8010 Graz, Austria

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2011年 / 400卷 / 08期

关键词：

Ligand-exchange; Chiral selectors; Chemically bonded phases; Dynamically coated phases; Monolithic phases; HPLC; Capillary electrophoresis; Capillary electrochromatography; AMINO-ACID ENANTIOMERS; MONOLITHIC SILICA COLUMN; ALPHA-HYDROXY ACIDS; SOL-GEL PROCESS; CAPILLARY-ELECTROPHORESIS; OPTICAL ISOMERS; CONTINUOUS BEDS; LIQUID-CHROMATOGRAPHY; CU(II) COMPLEXES; BORATE ANION;

D O I：

10.1007/s00216-011-4737-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This article gives a short overview of the application of the principle of chiral ligand-exchange in HPLC, CE, and CEC. Since its introduction by Davankov, more than thousand articles have appeared in this field. Citing all these papers would extend the scope of this review-it would fill several books. Therefore only some milestones are mentioned in this article and it will focus on our own activities in this field. Some new developments are mentioned, and selected biochemical and biomedical application are presented.

引用

页码：2305 / 2316

页数：12

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