Semi-blind source extraction of atrial activity by combining statistical and spectral features

Atrial fibrillation is the most common human arrhythmia. During atrial fibrillation episodes, the surface electrocardiogram contains the linear superposition of the atrial and ventricular rhythms in addition to other non-cardiac artifacts. Since these signals can be considered statistically independent, a Blind Source Separation (BSS) approach fits the problem properly. The signal that contains useful clinical information is the atrial one. We present a solution that focuses on the extraction of the atrial activity, enforcing simultaneously the statistical and temporal properties of the atrial signal. In addition, we propose the use of kurtosis as a parameter to measure the quality of the extraction. The algorithm is applied successfully to synthetic and real data. It improves the extraction of the atrial signal in comparison to other BSS methods, recovers only the interesting atrial rhythm using the information contained in all the leads and reduces the computational cost. The results obtained are shown to be highly satisfactory, with an average of 53.9% of spectral concentration, -0.04 of kurtosis value, 2.98 of ventricular residua and 4.77% of significant QRS residua over a database of thirty patients. (C) 2010 Elsevier Inc. All rights reserved.