The TB Structural Genomics Consortium: A decade of progress

被引：28

作者：

Chim, Nicholas ^{[1
]}

Habel, Jeff E. ^{[2
]}

Johnston, Jodie M. ^{[3
,4
]}

Krieger, Inna ^{[5
]}

Miallau, Linda ^{[6
]}

Sankaranarayanan, Ramasamy ^{[7
]}

Morse, Robert P. ^{[1
]}

Bruning, John ^{[5
]}

Swanson, Stephanie ^{[5
]}

Kim, Haelee ^{[5
]}

Kim, Chang-Yub ^{[8
]}

Li, Hongye ^{[9
]}

Bulloch, Esther M. ^{[3
,4
]}

Payne, Richard J. ^{[10
]}

Manos-Turvey, Alexandra ^{[10
]}

Hung, Li-Wei ^{[2
,8
]}

Baker, Edward N. ^{[3
,4
]}

Lott, J. Shaun ^{[3
,4
]}

James, Michael N. G. ^{[7
]}

Terwilliger, Thomas C. ^{[8
]}

Eisenberg, David S. ^{[6
]}

Sacchettini, James C. ^{[5
]}

Goulding, Celia W. ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA

[2] Univ Calif Berkeley, Lawrence Berkeley Lab, Phys Biosci Div, Berkeley, CA 94720 USA

[3] Univ Auckland, Sch Biol Sci, Auckland 1142, New Zealand

[4] Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovery, Auckland 1142, New Zealand

[5] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA

[6] Univ Calif Los Angeles, UCLA DOE Lab Struct Biol, Howard Hughes Med Inst, Inst Mol Biol, Los Angeles, CA 90095 USA

[7] Univ Alberta, Grp Prot Struct & Funct, Dept Biochem, Sch Mol & Syst Med,Fac Med & Dent, Edmonton, AB T6G 2H7, Canada

[8] Los Alamos Natl Lab, Los Alamos, NM 87545 USA

[9] Texas A&M Univ, Inst Biosci & Technol, Houston, TX 77030 USA

[10] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

TUBERCULOSIS | 2011年 / 91卷 / 02期

关键词：

Mycobacterium tuberculosis; Protein structure; X-ray crystallography; Structural genomics; Drug discovery; HEME-DEGRADING ENZYMES; MYCOBACTERIUM-TUBERCULOSIS UREASE; PARA-AMINOBENZOATE SYNTHESIS; SMALL-MOLECULE INHIBITORS; DISULFIDE BOND FORMATION; TOXIN-ANTITOXIN MODULES; ESCHERICHIA-COLI; PROTEIN FUNCTION; MALATE SYNTHASE; OUTER-MEMBRANE;

D O I：

10.1016/j.tube.2010.11.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The TB Structural Genomics Consortium is a worldwide organization of collaborators whose mission is the comprehensive structural determination and analyses of Mycobacterium tuberculosis proteins to ultimately aid in tuberculosis diagnosis and treatment. Congruent to the overall vision, Consortium members have additionally established an integrated facilities core to streamline M. tuberculosis structural biology and developed bioinformatics resources for data mining. This review aims to share the latest Consortium developments with the TB community, including recent structures of proteins that play significant roles within M. tuberculosis. Atomic resolution details may unravel mechanistic insights and reveal unique and novel protein features, as well as important protein-protein and protein-ligand interactions, which ultimately lead to a better understanding of M. tuberculosis biology and may be exploited for rational, structure-based therapeutics design. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：155 / 172

页数：18

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