Nanoengineered Electroconductive Collagen-Based Cardiac Patch for infarcted Myocardium Repair

被引：81

作者：

Hosoyama, Katsuhiro ^{[1
]}

Ahumada, Manuel ^{[1
,2
,3
,8
]}

McTiernan, Christopher D. ^{[1
,2
,3
]}

Davis, Darryl R. ^{[4
,5
]}

Variola, Fabio ^{[6
]}

Ruel, Marc ^{[1
,5
]}

Liang, Wenbin ^{[5
,7
]}

Suuronen, Erik J. ^{[1
,5
]}

Alarcon, Emilio I. ^{[1
,2
,3
]}

机构：

[1] Univ Ottawa, Div Cardiac Surg, Heart Inst, Ottawa, ON K1Y 4W7, Canada

[2] Univ Ottawa, Fac Med, Bionanomat Chem & Engn Lab, Ottawa, ON K1H 8M5, Canada

[3] Univ Ottawa, Fac Med, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada

[4] Univ Ottawa, Dept Med, Div Cardiol, Heart Inst, Ottawa, ON K1Y 4W7, Canada

[5] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON K1H 8M5, Canada

[6] Univ Ottawa, Dept Mech Engn, Ottawa, ON K1N 6N5, Canada

[7] Univ Ottawa, Cardiac Electrophysiol Lab, Heart Inst, Ottawa, ON K1Y 4W7, Canada

[8] Harvard Med Sch, Massachusetts Gen Hosp, Wellman Ctr Photomed, 40 Blossom St, Boston, MA 02114 USA

来源：

ACS APPLIED MATERIALS & INTERFACES | 2018年 / 10卷 / 51期

基金：

加拿大健康研究院; 加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

nanomaterials; collagen fibers; extracellular matrix; myocardial infarction; electroconductive materials; cardiac tissue repair; regenerative medicine; CARBON NANOTUBES; ELECTRICAL-STIMULATION; ALGINATE-HYDROGEL; HEART-FAILURE; MATRIX; EXPRESSION; MYOCYTES; THERAPY; NANOMATERIALS; MACROPHAGES;

D O I：

10.1021/acsami.8b18844

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

We have prepared and tested in vivo a novel nanoengineered hybrid electroconductive cardiac patch for treating the infarcted myocardium. Of the prepared and tested patches, only those containing spherical nanogold were able to increase connexin-43 expression in neonatal rat cardiomyocytes cultured under electrical stimulation. In vivo data indicated that only nano gold-containing patches were able to recover cardiac function. Histological analysis also revealed that connexin-43 levels and blood vessel density were increased, while the scar size was reduced for animals that received the nanogold patch. Thus, our study indicates that the incorporation of electroconductive properties into a collagen-based cardiac patch can improve its therapeutic potential for treating myocardial infarction.

引用

页码：44668 / 44677

页数：10

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