New general strategy of dimerization of bioactive molecules

被引：7

作者：

Giraud, M

Bernad, N

Martinez, J

Cavelier, F ^{[1
]}

机构：

[1] Univ Montpellier 1, UMR CNRS 5810, Lab Aminoacides Peptides & Prot, F-34095 Montpellier 05, France

[2] Univ Montpellier 2, UMR CNRS 5810, Lab Aminoacides Peptides & Prot, F-34095 Montpellier, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 10期

关键词：

D O I：

10.1016/S0040-4039(01)00053-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe a new way of obtaining dimeric structures based on intermolecular diketopiperazine formation. The bioactive substance to dimerize was first linked to a glycine moiety. Then a coupling step using DMAP in stoichiometric quantity resulted in the cyclization involving both C-terminal carboxylic functions and the amide nitrogen. This general strategy has been applied to peptide and non-peptide bioactive molecules. (C) 2001 Published by Elsevier Science Ltd.

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页码：1895 / 1897

页数：3

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