Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: Lack of association with clinical phenotypes

被引：6
作者：
Kocabas, Neslihan Aygun [1 ,2 ]
Antonijevic, Irina
Faghel, Carole [1 ]
Forray, Carlos
Kasper, Siegfried [3 ]
Lecrubier, Yves [4 ]
Linotte, Sylvie
Massat, Isabelle [1 ]
Montgomery, Stuart [5 ]
Noro, Magali
Oswald, Pierre
Snyder, Lenore
Souery, Daniel [6 ,7 ]
Zohar, Joseph [8 ]
Mendlewicz, Julien
机构：
[1] Univ Libre Bruxelles, Lab Neurol Expt, Fonds Rech Sci FNRS, B-1070 Brussels, Belgium
[2] Gazi Univ, Fac Pharm, Dept Toxicol, Ankara, Turkey
[3] Med Univ Vienna, Dept Gen Psychiat, Vienna, Austria
[4] Hop La Pitie Salpetriere, INSERM, U302, Paris, France
[5] Univ London Imperial Coll Sci Technol & Med, Sch Med, London, England
[6] Univ Libre Bruxelles, Lab Psychol Med, B-1070 Brussels, Belgium
[7] Ctr Europeen Psychol Med, Brussels, Belgium
[8] Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel
来源：
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY | 2010年 / 11卷 / 08期
关键词：
DTNBP1 (dystrobrevin binding protein 1); major depressive disorder (MDD); clinical phenotypes; treatment response; SNP; DYSTROBREVIN-BINDING PROTEIN-1; NEUROTROPHIC FACTOR; NEGATIVE SYMPTOMS; SCHIZOPHRENIA; BRAIN; EXPRESSION; POLYMORPHISMS;
D O I：
10.3109/15622975.2010.512089
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Objectives. Dystrobrevin binding protein 1 (Dysbindin) is a plausible candidate gene for major depressive disorders (MDD) due to its involvement in synaptic signaling, plasticity and localization in the brain. Methods. Two intronic SNPs of DTNBP1; rs760761 (P1320) and rs2619522 (P1763) were analyzed in 206 patients with DSM-IV MDD to investigate the functional impact of genotypes on susceptibility for depression and some clinical phenotypes. The Sequenom iPLEX assay (Sequenom, Cambridge, MA) was used for genotyping. Results and Conclusions. Despite the limited power of analysis, our results showed that these two SNPs in DTNPB1 gene were not related to clinical phenotypes such as melancholia, age at onset, suicidality and co-morbid anxiety disorders, as well as to treatment response phenotypes.
引用
收藏
页码：985 / 990
页数：6
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