Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces sps. YIM56132 and YIM56141

被引:22
作者
Huang, Sheng-Xiong [1 ]
Yu, Zhiguo [1 ]
Robert, Francis [2 ,3 ]
Zhao, Li-Xing [4 ]
Jiang, Yi [4 ]
Duan, Yanwen
Pelletier, Jerry [2 ,3 ]
Shen, Ben [1 ,5 ,6 ]
机构
[1] Univ Wisconsin, Div Pharmaceut Sci, Sch Pharm, Madison, WI 53705 USA
[2] McGill Univ, Dept Biochem, Montreal, PQ, Canada
[3] McGill Univ, Rosalind & Morris Goodman Canc Res Ctr, Montreal, PQ, Canada
[4] Yunnan Univ, Yunnan Inst Microbiol, Kunming, Yunnan, Peoples R China
[5] Univ Wisconsin, Univ Wisconsin Natl Cooperat Drug Discovery Grp, Madison, WI 53705 USA
[6] Univ Wisconsin, Dept Chem, Madison, WI 53705 USA
关键词
cycloheximide; endophytes; eukaryotic protein synthesis inhibitor; glutarimide-containing polyketide; Streptomyces sp YIM56132; Streptomyces sp YIM56141; TRANSLATION INITIATION; LACTIMIDOMYCIN; BIOSYNTHESIS; MIGRASTATIN; DORRIGOCIN;
D O I
10.1038/ja.2010.150
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
[No abstract available]
引用
收藏
页码:163 / 166
页数:4
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