Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces sps. YIM56132 and YIM56141

被引：22

作者：

Huang, Sheng-Xiong ^{[1
]}

Yu, Zhiguo ^{[1
]}

Robert, Francis ^{[2
,3
]}

Zhao, Li-Xing ^{[4
]}

Jiang, Yi ^{[4
]}

Duan, Yanwen

Pelletier, Jerry ^{[2
,3
]}

Shen, Ben ^{[1
,5
,6
]}

机构：

[1] Univ Wisconsin, Div Pharmaceut Sci, Sch Pharm, Madison, WI 53705 USA

[2] McGill Univ, Dept Biochem, Montreal, PQ, Canada

[3] McGill Univ, Rosalind & Morris Goodman Canc Res Ctr, Montreal, PQ, Canada

[4] Yunnan Univ, Yunnan Inst Microbiol, Kunming, Yunnan, Peoples R China

[5] Univ Wisconsin, Univ Wisconsin Natl Cooperat Drug Discovery Grp, Madison, WI 53705 USA

[6] Univ Wisconsin, Dept Chem, Madison, WI 53705 USA

来源：

JOURNAL OF ANTIBIOTICS | 2011年 / 64卷 / 01期

关键词：

cycloheximide; endophytes; eukaryotic protein synthesis inhibitor; glutarimide-containing polyketide; Streptomyces sp YIM56132; Streptomyces sp YIM56141; TRANSLATION INITIATION; LACTIMIDOMYCIN; BIOSYNTHESIS; MIGRASTATIN; DORRIGOCIN;

D O I：

10.1038/ja.2010.150

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

[No abstract available]

引用

页码：163 / 166

页数：4

共 22 条

[1] Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model [J].

Bordeleau, Marie-Eve ;

Robert, Francis ;

Gerard, Baudouin ;

Lindqvist, Lisa ;

Chen, Samuel M. H. ;

Wendel, Hans-Guido ;

Brem, Brigitte ;

Greger, Harald ;

Lowe, Scott W. ;

Porco, John A., Jr. ;

Pelletier, Jerry .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (07) :2651-2660

[2] Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A [J].

Bordeleau, ME ;

Mori, A ;

Oberer, M ;

Lindqvist, L ;

Chard, LS ;

Higa, T ;

Belsham, GJ ;

Wagner, G ;

Tanaka, J ;

Pelletier, J .

NATURE CHEMICAL BIOLOGY, 2006, 2 (04) :213-220

[3] Identifying small molecule inhibitors of eukaryotic translation initiation [J].

Cencic, Regina ;

Robert, Francis ;

Pelletier, Jerry .

TRANSLATION INITIATION: CELL BIOLOGY, HIGH-THROUGHPUT METHODS, AND CHEMICAL-BASED APPROACHES, 2007, 431 :269-302

[4] Yeast Glycogen Synthase Kinase-3β Pathway Inhibitors from an Organic Extract of Streptomyces sp. [J].

Cheenpracha, Sarot ;

Zhang, Hui ;

Mar, Annie M. N. ;

Foss, Adam P. ;

Foo, Sek Hin ;

Lai, Ngit Shin ;

Jee, Jap Meng ;

Seow, Heng Fong ;

Ho, Coy Choke ;

Chang, Leng Chee .

JOURNAL OF NATURAL PRODUCTS, 2009, 72 (08) :1520-1523

[5] STRUCTURE-ACTIVITY STUDIES WITH CYCLOHEXIMIDE AND CONGENERS [J].

ENNIS, HL .

BIOCHEMICAL PHARMACOLOGY, 1968, 17 (07) :1197-&

[6] Phenatic acids A and B, new potentiators of antifungal miconazole activity produced by Streptomyces sp K03-0132 [J].

Fukuda, T ;

Matsumoto, A ;

Takahashi, Y ;

Tomoda, H ;

Omura, S .

JOURNAL OF ANTIBIOTICS, 2005, 58 (04) :252-259

[7] Discovery and Total Synthesis of a New Estrogen Receptor Heterodimerizing Actinopolymorphol A from Actinopolymorpha rutilus [J].

Huang, Sheng-Xiong ;

Powell, Emily ;

Rajski, Scott R. ;

Zhao, Li-Xing ;

Jiang, Cheng-Lin ;

Duan, Yanwen ;

Xu, Wei ;

Shen, Ben .

ORGANIC LETTERS, 2010, 12 (15) :3525-3527

[8] Erythronolides H and I, New Erythromycin Congeners from a New Halophilic Actinomycete Actinopolyspora sp YIM90600 [J].

Huang, Sheng-Xiong ;

Zhao, Li-Xing ;

Tang, Shu-Kun ;

Jiang, Cheng-Lin ;

Duan, Yanwen ;

Shen, Ben .

ORGANIC LETTERS, 2009, 11 (06) :1353-1356

[9] C-13 NUCLEAR MAGNETIC-RESONANCE STUDY OF THE BIOSYNTHESIS OF CYCLOHEXIMIDE - STEREOSPECIFIC INCORPORATION OF MALONATE INTO THE GLUTARIMIDE RING [J].

JEFFS, PW ;

MCWILLIAMS, D .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (20) :6185-6192

[10] Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds [J].

Ju, JH ;

Lim, SK ;

Jiang, H ;

Seo, JW ;

Shen, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (34) :11930-11931

← 1 2 3 →