Synergy between Colistin and the Signal Peptidase Inhibitor MD3 Is Dependent on the Mechanism of Colistin Resistance in Acinetobacter baumannii

被引：6

作者：

Martinez-Guitan, Marta ^{[1
]}

Vazquez-Ucha, Juan C. ^{[1
]}

Odingo, Joshua ^{[2
]}

Parish, Tanya ^{[2
]}

Poza, Margarita ^{[1
]}

Waite, Richard D. ^{[3
]}

Bou, German ^{[1
]}

Wareham, David W. ^{[3
]}

Beceiro, Alejandro ^{[1
]}

机构：

[1] Inst Invest Biomed INIBIC, Microbiol Serv, Coruna, Spain

[2] Infect Dis Res Inst, TB Discovery Res, Seattle, WA USA

[3] Queen Mary Univ London, Barts & London Sch Med & Dent, Antimicrobial Res Grp, London, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 07期

关键词：

EMERGENCE; VIRULENCE; COMBINATION; INFECTIONS; THERAPY; SYSTEM; IMPACT;

D O I：

10.1128/AAC.00510-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Synergy between colistin and the signal peptidase inhibitor MD3 was tested against isogenic mutants and clinical pairs of Acinetobacter baumannii isolates. Checkerboard assays and growth curves showed synergy against both colistin-susceptible strains (fractional inhibitory concentration index [FICindex] = 0.13 to 0.24) and colistin-resistant strains with mutations in pmrB and phosphoethanolamine modification of lipid A (FICindex = 0.14 to 0.25) but not against colistin-resistant Delta lpx strains with loss of lipopolysaccharide (FICindex = 0.75 to 1). A colistin/MD3 combination would need to be targeted to strains with specific colistin resistance mechanisms.

引用

页码：4375 / 4379

页数：5

共 5 条

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