The Biological Basis of Thrombosis and Bleeding in Patients with Ventricular Assist Devices

被引：42

作者：

John, Ranjit ^{[1
,2
]}

Lee, Sangjin ^{[3
]}

机构：

[1] Univ Minnesota, Div Cardiothorac Surg, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Surg, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2009年 / 2卷 / 01期

关键词：

Ventricular Assist Devices; Bleeding; Thrombosis; Heart Failure; TISSUE FACTOR EXPRESSION; VON-WILLEBRAND-FACTOR; SICKLE-CELL-ANEMIA; ENDOTHELIAL-CELLS; AORTIC-STENOSIS; LVAD RECIPIENTS; THROMBOEMBOLIC COMPLICATIONS; HEART-TRANSPLANTATION; CIRCULATORY SUPPORT; SYSTEM;

D O I：

10.1007/s12265-008-9072-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The clinical success of left ventricular assist devices (LVADs) has been tempered by significant hemorrhagic and thromboembolic complications. In the case of LVADs, where the biomaterial is in direct contact with the blood circulation, significant changes in systemic immunologic and thrombostatic functions have been well documented. Although further investigation is warranted, significant advances have been made in both cellular biology and LVAD technology to better understand the delicate balance between the procoagulant milieu predisposing to thrombosis and the risks of both surgical and non-surgical bleeding.

引用

页码：63 / 70

页数：8

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