Reduced vagal activity in salt-sensitive subjects during mental challenge

被引:33
作者
Buchholz, K
Schächinger, H
Wagner, M
Sharma, AM
Deter, HC
机构
[1] Free Univ Berlin, Benjamin Franklin Med Ctr, Div Psychosomat Med, D-1000 Berlin, Germany
[2] Univ Basel Hosp, Dept Med, Div Psychosomat Med, CH-4031 Basel, Switzerland
[3] Free Univ Berlin, Benjamin Franklin Med Ctr, Div Psychosomat Med, Berlin, Germany
[4] Humboldt Univ, Fac Med Charite, Franz Volhard Klin, Berlin, Germany
[5] Max Delbruck Ctr Mol Med, Berlin, Germany
关键词
Heart rate variability; vagal activity; mental stress; sodium-dependent hypertension; blood pressure; HEART-RATE-VARIABILITY; POWER SPECTRUM ANALYSIS; BLOOD-PRESSURE; SHORT-TERM; HUMANS; HYPERTENSION; STRESS; SODIUM; REACTIVITY;
D O I
10.1016/S0895-7061(03)00905-1
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Background: Salt-sensitive normotensive men exhibit an enhanced pressor and heart rate (HR) response to mental stress. Stress-induced HR acceleration may result from sympathetic activation or vagal withdrawal. We studied the importance of vagal withdrawal for the increased stress responsiveness of salt-sensitive subjects. Methods: We studied cardiovascular reactivity to mental challenge in 17 salt-sensitive healthy white male students and 56 salt-resistant control subjects who were comparable with respect to age, body mass index, and physical fitness. Salt sensitivity was determined by a 2-week dietary protocol (20 mmol v 240 mmol sodium/day). Mental stress was induced by a computerized information-processing task (manometer test). Electrocardiogram and finger blood pressure (BP; Finapres, Ohmeda, Louisville, CO) were registered continuously to determine HR and interbeat-interval length. Time and frequency domain (spectral power) based measures of respiratory-related heart rate variability (HRV) were calculated to estimate vagal cardiac control; diastolic BP reactivity was assessed to estimate peripheral sympathetic effects. Results: Stress-induced increase in HR was higher in salt-sensitive than in salt-resistant subjects. Salt-sensitive subjects, in comparison to salt-resistant subjects, showed significantly reduced respiratory-related HRV during baseline and mental stress conditions (P < .01). The increase in diastolic BP during mental challenge was significantly greater in salt-sensitive subjects (P < .05). Conclusions: Our findings suggest reduced vagal and increased sympathetic tone during mental challenge in salt-sensitive subjects. Altered autonomic nervous system function may contribute to later development of hypertension in salt-sensitive individuals. (C) 2003 American Journal of Hypertension, Ltd.
引用
收藏
页码:531 / 536
页数:6
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