Effect of water on the palladium-catalyzed amidation of aryl bromides

被引：47
作者：
Dallas, AS
Gothelf, KV
机构：
[1] Aarhus Univ, Dept Chem, Interdisciplinary Nanosci Ctr, DK-8000 Aarhus, Denmark
[2] Aarhus Univ, Dept Chem, Ctr Catalysis, DK-8000 Aarhus, Denmark
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 08期
关键词：
D O I：
10.1021/jo0500176
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The presence of water was found to have a significant impact on the conversion of some Hartwig-Buchwald reactions between amides with arylbromides. Seven amidation reactions were studied in a series of experiments containing 0-400 mol % water. When cesium carbonate is used as the base both in dioxane and toluene, water can have a beneficial effect. The experiments have also shown that for some reactions, anhydrous conditions are unnecessary and sometimes can hinder the reaction.
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页码：3321 / 3323
页数：3
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