Time-resolved photon emission from layered turbid media

被引:78
作者
Hielscher, AH
Liu, HL
Chance, B
Tittel, FK
Jacques, SL
机构
[1] RICE UNIV,DEPT ELECT & COMP ENGN,HOUSTON,TX 77251
[2] UNIV PENN,DEPT BIOCHEM & BIOPHYS,PHILADELPHIA,PA 19104
[3] UNIV TEXAS,MD ANDERSON CANCER CTR,LASER BIOL RES LAB,HOUSTON,TX 77030
来源
APPLIED OPTICS | 1996年 / 35卷 / 04期
关键词
diffusion theory; photon migration; scattering; time-resolved; photon counting; reflectance; multilayer; Monte Carlo simulation; tissue phantom; blood oxygenation; brain;
D O I
10.1364/AO.35.000719
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We present numerical and experimental results of time-resolved emission profiles from various layered turbid media. Numerical solutions determined by time-resolved Monte Carlo simulations are compared with measurements on layered-tissue phantoms made from gelatin. In particular, we show that in certain cases the effects of the upper layers can be eliminated. As a practical example, these results are used to analyze in vivo measurements on the human head. This demonstrates the influence of skin, skull, and meninges on the determination of the blood oxygenation in the brain. (C) 1996 Optical Society of America
引用
收藏
页码:719 / 728
页数:10
相关论文
共 23 条
[1]   NONINVASIVE METHODS FOR ESTIMATING INVIVO OXYGENATION [J].
BENARON, DA ;
BENITZ, WE ;
ARIAGNO, RL ;
STEVENSON, DK .
CLINICAL PEDIATRICS, 1992, 31 (05) :258-273
[2]   COMPARISON OF TIME-RESOLVED AND TIME-UNRESOLVED MEASUREMENTS OF DEOXYHEMOGLOBIN IN BRAIN [J].
CHANCE, B ;
LEIGH, JS ;
MIYAKE, H ;
SMITH, DS ;
NIOKA, S ;
GREENFELD, R ;
FINANDER, M ;
KAUFMANN, K ;
LEVY, W ;
YOUNG, M ;
COHEN, P ;
YOSHIOKA, H ;
BORETSKY, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (14) :4971-4975
[3]   THE RELATIONSHIP OF SURFACE REFLECTANCE MEASUREMENTS TO OPTICAL-PROPERTIES OF LAYERED BIOLOGICAL MEDIA [J].
CUI, WJ ;
OSTRANDER, LE .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1992, 39 (02) :194-201
[4]  
Duck F., 1990, Physical Properties of Tissue, P43
[5]   OPTICAL-PROPERTIES OF HUMAN-BRAIN TISSUE, MENINGES, AND BRAIN-TUMORS IN THE SPECTRAL RANGE OF 200 TO 900 NM [J].
EGGERT, HR ;
BLAZEK, V .
NEUROSURGERY, 1987, 21 (04) :459-464
[6]   MONTE-CARLO MODELING OF LIGHT-PROPAGATION IN HIGHLY SCATTERING TISSUES .2. COMPARISON WITH MEASUREMENTS IN PHANTOMS [J].
FLOCK, ST ;
WILSON, BC ;
PATTERSON, MS .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1989, 36 (12) :1169-1173
[7]  
HIELSCHER AH, 1994, P SOC PHOTO-OPT INS, V2136, P4, DOI 10.1117/12.180773
[8]   THE INFLUENCE OF BOUNDARY-CONDITIONS ON THE ACCURACY OF DIFFUSION-THEORY IN TIME-RESOLVED REFLECTANCE SPECTROSCOPY OF BIOLOGICAL TISSUES [J].
HIELSCHER, AH ;
JACQUES, SL ;
WANG, LH ;
TITTEL, FK .
PHYSICS IN MEDICINE AND BIOLOGY, 1995, 40 (11) :1957-1975
[9]  
JACQUES SL, 1995, OPTICAL THERMAL RESP, pCH9
[10]   NONINVASIVE, INFRARED MONITORING OF CEREBRAL AND MYOCARDIAL OXYGEN SUFFICIENCY AND CIRCULATORY PARAMETERS [J].
JOBSIS, FF .
SCIENCE, 1977, 198 (4323) :1264-1267