Protective effect of Fragarria ananassa and Vaccinium corymbosum fruit extracts against L-arginine induced acute pancreatitis in rats

被引：1
|
作者：
Gadicherla, Veena [1 ,2 ]
Challa, Siva Reddy [3 ]
Rao, Mandava V. Basaveswara [4 ]
Ramakrishna, P. [5 ]
Kumar, K. Pavan [6 ]
机构：
[1] Krishna Univ, Fac Pharmaceut Sci, Dept Pharmacol, Machilipatnam 521001, Andhra Pradesh, India
[2] Sri Indu Inst Pharm, Dept Pharmacol, Ibrahimpatnam 501510, Andhra Pradesh, India
[3] KVSR Siddhartha Inst Pharmaceut Sci, Dept Pharmacol, Vijayawada 520010, Andhra Pradesh, India
[4] Krishna Univ, Fac Pharmaceut Sci, Dept Chem, Machilipatnam 521001, Andhra Pradesh, India
[5] Krishna Univ, Fac Pharmaceut Sci, Machilipatnam 521001, Andhra Pradesh, India
[6] Shadan Coll Pharm, Dept Pharmaceut Anal, Hyderabad 500086, Telangana, India
来源：
INDIAN JOURNAL OF ANIMAL RESEARCH | 2020年 / 54卷 / 01期
关键词：
Amylase; Blueberry; L-Arginine; Lipase; Oxygen free radicals; Pancreatitis; Strawberry; ANTIOXIDANT CAPACITY; BERRY POLYPHENOLS; FREE-RADICALS; NITRIC-OXIDE; ASSAY; ANTHOCYANINS; BLUEBERRIES; ANTICANCER; STRESS; TISSUE;
D O I：
10.18805/ijar.B-3737
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
The study was aimed to evaluate the protective effects of alcoholic extracts of Strawberry and Blueberry fruits [AESF and AEBF] in acute pancreatitis in rats. Treatment groups received AESF and AEBF at doses of 200 and 400 mg/kg for 7 days with prior injections of L-arginine on 5th day. Biochemical parameters were estimated in serum and pancreatic tissue samples. Histopathological studies and DNA fragmentation assay were carried out in isolated pancreatic tissue. The results of the study indicated that treatment of AESF and AEBF exhibited a significant dose dependent protective effect. Upon the treatment, anti-oxidant enzymes were significantly (*p<0.05) increased. Biochemical results were correlated with the histopathological findings. In addition, the DNA fragmentation assay showed an intact DNA in pancreatic cells of treated groups. In conclusion, berry fruit extracts exerted a potential protective effect against L-arginine induced damage in rat pancreas, at least in part, due to its antioxidant properties.
引用
收藏
页码：74 / 82
页数：9
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