The epidemiology and therapeutic options for the COVID-19

被引:12
作者
Li, Jingwei [1 ]
Shao, Jun [1 ]
Wang, Chengdi [1 ]
Li, Weimin [1 ]
机构
[1] Sichuan Univ, West China Hosp, West China Med Sch, Dept Resp & Crit Care Med, Chengdu 610041, Peoples R China
基金
中国国家自然科学基金;
关键词
coronavirus disease 2019; COVID-19; epidemiology; clinical features; treatment; CLINICAL CHARACTERISTICS; CORONAVIRUS; SARS-COV-2; WUHAN; TRANSMISSION; COMBINATION; TARGETS; VACCINE; BINDING; PROTEIN;
D O I
10.1093/pcmedi/pbaa017
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
An outbreak of coronavirus disease 2019 (COVID-19), a disease caused by a novel pneumonia virus, has affected over 200 countries and regions worldwide. With the increasing number of patients and deaths, WHO have declared it as a global pandemic currently, indicating a third large-scale epidemic coronavirus has appeared since the emergence of severe acute respiratory syndrome coronavirus (SARS) and Middle-East respiratory syndrome (MERS) in the twenty-first century. Considering the great harm it has caused, researchers throughout the world have been chasing to exploit the pathophysiology, characteristics, and potential remedies for COVID-19 to better battle the outbreak. Therefore, the current study revisits advances of the virology, epidemiology, clinical features, therapeutic options, and prevention of COVID-19. The features of asymptomatic carriers are also been explored.
引用
收藏
页码:71 / 84
页数:14
相关论文
共 140 条
[1]   Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies [J].
Ahmed, Syed Faraz ;
Quadeer, Ahmed A. ;
McKay, Matthew R. .
VIRUSES-BASEL, 2020, 12 (03)
[2]  
[Anonymous], 2020, Radiology, DOI DOI 10.1148/RADIOL.2020200642
[3]   CRISPR-Cas14 is now part of the artillery for gene editing and molecular diagnostic [J].
Aquino-Jarquin, Guillermo .
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2019, 18 :428-431
[4]   Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State [J].
Arentz, Matt ;
Yim, Eric ;
Klaff, Lindy ;
Lokhandwala, Sharukh ;
Riedo, Francis X. ;
Chong, Maria ;
Lee, Melissa .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (16) :1612-1614
[5]  
Atluri S, 2020, PAIN PHYSICIAN, V23, pE71
[6]   Presumed Asymptomatic Carrier Transmission of COVID-19 [J].
Bai, Yan ;
Yao, Lingsheng ;
Wei, Tao ;
Tian, Fei ;
Jin, Dong-Yan ;
Chen, Lijuan ;
Wang, Meiyun .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (14) :1406-1407
[7]   The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice [J].
Bao, Linlin ;
Deng, Wei ;
Huang, Baoying ;
Gao, Hong ;
Liu, Jiangning ;
Ren, Lili ;
Wei, Qiang ;
Yu, Pin ;
Xu, Yanfeng ;
Qi, Feifei ;
Qu, Yajin ;
Li, Fengdi ;
Lv, Qi ;
Wang, Wenling ;
Xue, Jing ;
Gong, Shuran ;
Liu, Mingya ;
Wang, Guanpeng ;
Wang, Shunyi ;
Song, Zhiqi ;
Zhao, Linna ;
Liu, Peipei ;
Zhao, Li ;
Ye, Fei ;
Wang, Huijuan ;
Zhou, Weimin ;
Zhu, Na ;
Zhen, Wei ;
Yu, Haisheng ;
Zhang, Xiaojuan ;
Guo, Li ;
Chen, Lan ;
Wang, Conghui ;
Wang, Ying ;
Wang, Xinming ;
Xiao, Yan ;
Sun, Qiangming ;
Liu, Hongqi ;
Zhu, Fanli ;
Ma, Chunxia ;
Yan, Lingmei ;
Yang, Mengli ;
Han, Jun ;
Xu, Wenbo ;
Tan, Wenjie ;
Peng, Xiaozhong ;
Jin, Qi ;
Wu, Guizhen ;
Qin, Chuan .
NATURE, 2020, 583 (7818) :830-+
[8]  
Biontech SE, 2020, STUDY DESCRIBE SAFET
[9]   Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality [J].
Bonow, Robert O. ;
Fonarow, Gregg C. ;
O'Gara, Patrick T. ;
Yancy, Clyde W. .
JAMA CARDIOLOGY, 2020, 5 (07) :751-753
[10]   Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection A Randomized Clinical Trial [J].
Borba, Mayla Gabriela Silva ;
Val, Fernando Fonseca Almeida ;
Sampaio, Vanderson Souza ;
Alexandre, Marcia Almeida Araujo ;
Melo, Gisely Cardoso ;
Brito, Marcelo ;
Mourao, Maria Paula Gomes ;
Brito-Sousa, Jose Diego ;
Baia-da-Silva, Djane ;
Guerra, Marcus Vinitius Farias ;
Hajjar, Ludhmila Abrahao ;
Pinto, Rosemary Costa ;
Balieiro, Antonio Alcirley Silva ;
Pacheco, Antonio Guilherme Fonseca ;
Santos, James Dean Oliveira, Jr. ;
Naveca, Felipe Gomes ;
Xavier, Mariana Simao ;
Siqueira, Andre Machado ;
Schwarzbold, Alexandre ;
Croda, Julio ;
Nogueira, Mauricio Lacerda ;
Romero, Gustavo Adolfo Sierra ;
Bassat, Quique ;
Fontes, Cor Jesus ;
Albuquerque, Bernardino Claudio ;
Daniel-Ribeiro, Claudio-Tadeu ;
Monteiro, Wuelton Marcelo ;
Lacerda, Marcus Vinicius Guimaraes .
JAMA NETWORK OPEN, 2020, 3 (04) :E208857