Influenza neuraminidase

被引：194

作者：

Air, Gillian M. ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, Oklahoma City, OK 73104 USA

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2012年 / 6卷 / 04期

关键词：

Influenza; NA activity; NA antigenicity; NA inhibitors; neuraminidase; A VIRUS NEURAMINIDASE; SIALIC-ACID; SUBSTRATE-SPECIFICITY; N9; NEURAMINIDASE; N2; HEMAGGLUTININ ACTIVITY; MONOCLONAL-ANTIBODIES; RECEPTOR SPECIFICITY; H1N1; KINETIC-PARAMETERS;

D O I：

10.1111/j.1750-2659.2011.00304.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Please cite this paper as: Air. (2012) Influenza neuraminidase. Influenza and Other Respiratory Viruses 6(4), 245256. Influenza neuraminidase is the target of two licensed antivirals that have been very successful, with several more in development. However, neuraminidase has been largely ignored as a vaccine target despite evidence that inclusion of neuraminidase in the subunit vaccine gives increased protection. This article describes current knowledge on the structure, enzyme activity, and antigenic significance of neuraminidase.

引用

页码：245 / 256

页数：12

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