Racial Disparity in Response to Prostate Cancer Systemic Therapies

被引：13

作者：

Bitting, Rhonda L. ^{[1
,2
]}

Goodman, Michael ^{[3
,4
]}

George, Daniel J. ^{[2
]}

机构：

[1] Durham VA Hlth Care Syst, Durham, NC 27705 USA

[2] Duke Univ, Duke Canc Inst, Ctr Prostate & Urol Canc, Duke Box 103861, Durham, NC 27710 USA

[3] Wake Forest Univ, Ctr Comprehens Canc, Winston Salem, NC 27101 USA

[4] WG Bill Hefner VA Med Ctr, 1601 Brenner Ave, Salisbury, NC 28144 USA

来源：

CURRENT ONCOLOGY REPORTS | 2020年 / 22卷 / 09期

关键词：

Metastatic prostate cancer; Racial disparities; African Americans; CRPC; Sipuleucel-T; Docetaxel; Abiraterone; AFRICAN-AMERICAN; SIPULEUCEL-T; SURVIVAL; MITOXANTRONE; ABIRATERONE; PREDNISONE; TRIALS; TUMORS; MEN;

D O I：

10.1007/s11912-020-00966-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose of Review In this review, we aim to describe racial differences in response to treatment for metastatic castration-resistant prostate cancer (mCRPC). Recent Findings Recent data suggests that, despite higher risk features, African Americans may respond better than Caucasians to systemic therapies for advanced prostate cancer. This improved response is not limited to one class of drugs but can be seen with androgen-pathway directed therapies, chemotherapy, bone-targeted therapy, and immunotherapy. The mechanisms for this are being further explored. African Americans may respond better to mCRPC treatments but validation in prospective clinical trials is needed.

引用

页数：5

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