Synthesis of new triazolyl-N,N-dialkyldithiocarbamates as antifungal agents

被引：42

作者：

Ozkirimli, S ^{[1
]}

Apak, TI

Kiraz, M

Yegenoglu, Y

机构：

[1] Istanbul Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34116 Istanbul, Turkey

[2] Istanbul Univ, Istanbul Fac Med, Microbiol & Clin Microbiol Dept, Istanbul, Turkey

[3] Univ Iowa, Carver Coll Med, Dept Biochem, Iowa City, IA 52242 USA

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2005年 / 28卷 / 11期

关键词：

triazole derivatives; dithiocarbamates; antifungal agents;

D O I：

10.1007/BF02978200

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N,N-Dialkylditihiocarbamate derivatives have been well known as broad-range fungicides. In this study, the triazole derivatives of ten new N,N-disubstituted dithiocarbamates (3a-j) were synthesized and their structures were identified by spectral and elemental analysis. Results of the antifungal activity studies showed that some of the compounds tested were active against M. canis, M. gypseum, and T rubrum at the concentration of 12.5 mu g/mL when clotrimazol was used as a standard.

引用

页码：1213 / 1218

页数：6