Synthesis of new triazolyl-N,N-dialkyldithiocarbamates as antifungal agents

被引:42
作者
Ozkirimli, S [1 ]
Apak, TI
Kiraz, M
Yegenoglu, Y
机构
[1] Istanbul Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34116 Istanbul, Turkey
[2] Istanbul Univ, Istanbul Fac Med, Microbiol & Clin Microbiol Dept, Istanbul, Turkey
[3] Univ Iowa, Carver Coll Med, Dept Biochem, Iowa City, IA 52242 USA
关键词
triazole derivatives; dithiocarbamates; antifungal agents;
D O I
10.1007/BF02978200
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
N,N-Dialkylditihiocarbamate derivatives have been well known as broad-range fungicides. In this study, the triazole derivatives of ten new N,N-disubstituted dithiocarbamates (3a-j) were synthesized and their structures were identified by spectral and elemental analysis. Results of the antifungal activity studies showed that some of the compounds tested were active against M. canis, M. gypseum, and T rubrum at the concentration of 12.5 mu g/mL when clotrimazol was used as a standard.
引用
收藏
页码:1213 / 1218
页数:6
相关论文
共 23 条
[1]  
[Anonymous], INDIAN J PHYS NAT A
[2]   Synthesis and antimicrobial activity of some 5-aryl-2-[(N,N-disubstituted thiocarbamoylthio)acylamino]-1,3,4-oxadiazoles [J].
Ates, Ö ;
Kocabalkanli, A ;
Cesur, N ;
Ötük, G .
FARMACO, 1998, 53 (8-9) :541-544
[3]  
ATES O, 2003, ARCH PHARM PHARM MED, V1, P39
[4]  
CAPAN G, 1993, SCI PHARM, V61, P243
[5]  
CESUR N, 1994, ACTA PHARM TURC, V36, P74
[6]  
CREWS P, 1998, ORGANIC STRUCTURE AN, P93
[7]  
DASH AK, 2001, ANAL PROFILES DRUG S, V27, P89
[8]   Synthesis and antimicrobial properties of new 4-(alkylidene/arylidene)-amino-5-(2-furanyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones and 6-aryl-3-(2-furanyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines [J].
Ergenc, N ;
Ulusoy, N ;
Capan, G ;
Sanis, GO ;
Kiraz, M .
ARCHIV DER PHARMAZIE, 1996, 329 (8-9) :427-430
[9]  
Farghaly A O, 1999, Boll Chim Farm, V138, P280
[10]   Infectious disease 2001: drug resistance, new drugs [J].
Georgopapadakou, NH .
DRUG RESISTANCE UPDATES, 2002, 5 (05) :181-191