Early-life stress affects behavioral and neurochemical parameters differently in male and female juvenile Wistar rats

被引：0

作者：

Noschang, C. ^{[1
]}

Krolow, R. ^{[1
]}

Arcego, D. M. ^{[1
]}

Marcolin, M. ^{[1
]}

Ferreira, A. G. ^{[1
]}

Cunha, A. A. ^{[1
]}

Wyse, A. T. S. ^{[1
]}

Dalmaz, C. ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul UFRGS, Dept Bioquim, ICBS, 2600 Anexo,Lab 37, BR-90035003 Porto Alegre, RS, Brazil

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2020年 / 80卷 / 06期

关键词：

behavior; juvenile; neonatal handling; neurochemistry; sex differences; NA+; K+-ATPASE ACTIVITY; SPATIAL MEMORY; ACETYLCHOLINESTERASE; BRAIN; NEUROENDOCRINE; ADOLESCENCE; HABITUATION; INHIBITION; REACTIVITY; LOCOMOTION;

D O I：

10.1002/jdn.10050

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neonatal handling is an early life stressor that leads to behavioral and neurochemical changes in adult rats in a sex-specific manner and possibly affects earlier stages of development. Here, we investigated the effects of neonatal handling (days 1-10 after birth) on juvenile rats focusing on biochemical parameters and olfactory memory after weaning. Male neonatal handled rats performed more crossings on the hole-board task, increased Na+/K+-ATPase activity in the olfactory bulb, and decreased acetylcholinesterase activity in the hippocampus versus non-handled males. Female neonatal handled animals increased the number of rearing and nose-pokes on the hole-board task, decreased glutathione peroxidase activity, and total thiol content in the hippocampus versus non-handled females. This study reinforces that early life stress affects behavioral and neurochemical parameters in a sex-specific manner even before the puberty onset.

引用

页码：547 / 557

页数：11

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