Early-life stress affects behavioral and neurochemical parameters differently in male and female juvenile Wistar rats

被引：0
|
作者：
Noschang, C. [1 ]
Krolow, R. [1 ]
Arcego, D. M. [1 ]
Marcolin, M. [1 ]
Ferreira, A. G. [1 ]
Cunha, A. A. [1 ]
Wyse, A. T. S. [1 ]
Dalmaz, C. [1 ]
机构：
[1] Univ Fed Rio Grande do Sul UFRGS, Dept Bioquim, ICBS, 2600 Anexo,Lab 37, BR-90035003 Porto Alegre, RS, Brazil
来源：
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2020年 / 80卷 / 06期
关键词：
behavior; juvenile; neonatal handling; neurochemistry; sex differences; NA+; K+-ATPASE ACTIVITY; SPATIAL MEMORY; ACETYLCHOLINESTERASE; BRAIN; NEUROENDOCRINE; ADOLESCENCE; HABITUATION; INHIBITION; REACTIVITY; LOCOMOTION;
D O I：
10.1002/jdn.10050
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Neonatal handling is an early life stressor that leads to behavioral and neurochemical changes in adult rats in a sex-specific manner and possibly affects earlier stages of development. Here, we investigated the effects of neonatal handling (days 1-10 after birth) on juvenile rats focusing on biochemical parameters and olfactory memory after weaning. Male neonatal handled rats performed more crossings on the hole-board task, increased Na+/K+-ATPase activity in the olfactory bulb, and decreased acetylcholinesterase activity in the hippocampus versus non-handled males. Female neonatal handled animals increased the number of rearing and nose-pokes on the hole-board task, decreased glutathione peroxidase activity, and total thiol content in the hippocampus versus non-handled females. This study reinforces that early life stress affects behavioral and neurochemical parameters in a sex-specific manner even before the puberty onset.
引用
收藏
页码：547 / 557
页数：11
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