Synthesis, crystal structure, antibacterial and antitumor activities of a new Cadmium(II)-ciprofloxacin ionic compound

A new Cadmium(II)-ciprofloxacin ionic compound, (HCPFX)(2)[CdCl4](.)3H(2)O, is synthesized and its crystal structure is determined. The crystallography data are as follows, monoelinic, space group P2(1)/c, a=1.01039(6) rim, b=1.399 89(9) nm, c=2.82245(18) nm, beta=95.765 0(10)degrees, V=3.9720(4) nm(3), Z=4, D-c=1.627 g(.)cm(-3), F(000)= 1984. R,=0.054 0, wR(2)=0. 150 3 (1>2 sigma(1)). In the title compound, four chloride ions are coordinated to the cadmium ion forming a slightly distorted tetrahedron. Both Ciprofloxacin and the compound were assayed against gram-positive and gram-negative bacteria by doubling dilutions method, the compound shows the same minimal inhibitory concentration (MIC) as the Ciprofloxacin against S. Aureus, M. Luetens, E. Coli and P. Aeruginosa bacteria. The inhibitory effect of the two compounds on leukemia HL-60 cell line has been measured by using MTT (Methyl-Thiazol-Tetrozollum) assay method. The results indicate that the complex has very strong inhibitory effect on HL-60 cell line.