The nuclear envelope environment and its cancer connections

被引：267

作者：

Chow, Kin-Hoe ^{[1
]}

Factor, Rachel E. ^{[2
]}

Ullman, Katharine S. ^{[1
]}

机构：

[1] Univ Utah, Dept Oncol Sci, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Pathol, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 03期

关键词：

A-TYPE LAMINS; CELL-CYCLE PROGRESSION; DIFFERENTIAL EXPRESSION; NUP88; EXPRESSION; GENE-EXPRESSION; DNA-DAMAGE; RETINOBLASTOMA PROTEIN; NUCLEOPORIN NUP153; COLORECTAL-CANCER; OVARIAN-CANCER;

D O I：

10.1038/nrc3219

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Because of the association between aberrant nuclear structure and tumour grade, nuclear morphology is an indispensible criterion in the current pathological assessment of cancer. Components of the nuclear envelope environment have central roles in many aspects of cell function that affect tumour development and progression. As the roles of the nuclear envelope components, including nuclear pore complexes and nuclear lamina, are being deciphered in molecular detail there are opportunities to harness this knowledge for cancer therapeutics and biomarker development. In this Review, we summarize the progress that has been made in our understanding of the nuclear envelope and the implications of changes in this environment for cancer biology.

引用

页码：196 / 209

页数：14

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