Estradiol Increases Body Weight Loss and Gut-Peptide Satiation After Roux-en-Y Gastric Bypass in Ovariectomized Rats

被引：48
作者：
Asarian, Lori [1 ,2 ]
Abegg, Kathrin [1 ]
Geary, Nori
Schiesser, Marc [3 ]
Lutz, Thomas A. [1 ,2 ]
Bueter, Marco [2 ,3 ]
机构：
[1] Univ Zurich, Inst Vet Physiol, Vetsuisse Fac, CH-8057 Zurich, Switzerland
[2] Univ Zurich, Zurich Ctr Integrat Human Physiol, CH-8057 Zurich, Switzerland
[3] Univ Zurich Hosp, Div Visceral & Transplant Surg, Dept Surg, CH-8091 Zurich, Switzerland
来源：
GASTROENTEROLOGY | 2012年 / 143卷 / 02期
基金：
美国国家卫生研究院; 瑞士国家科学基金会;
关键词：
Bariatric Surgery; Obesity; CCK; GLP-1; BARIATRIC-SURGERY; OBESITY; ESTROGEN; TRENDS;
D O I：
10.1053/j.gastro.2012.05.008
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Despite the fact that similar to 85% of bariatric operations are performed in women, the effects of the reproductive axis function on outcome of bariatric surgery remain to be determined. Here we developed the first published model of Roux-en-Y gastric bypass (RYGB) in female rats. We show in ovariectomized rats receiving estradiol or control treatment that (1) RYGB-induced body weight loss and (2) the satiating efficacy of endogenous glucagon-like peptide-1 and cholecystokinin satiation were significantly increased in estradiol-treated rats. These data are relevant to the care of obese women, in particular perimenopausal women, undergoing bariatric surgery.
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页码：325 / +
页数：5
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