Diagnosis and Treatment of Ovarian Cancer

被引：260

作者：

Orr, Brian ^{[1
]}

Edwards, Robert P. ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Gynecol Oncol, 300 Halket St, Pittsburgh, PA 15213 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2018年 / 32卷 / 06期

关键词：

Ovarian cancer; Neoadjuvant; HIPEC; Intraperitoneal; Dose-dense; Chemotherapy; HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; ADVANCED EPITHELIAL OVARIAN; EARLY-STAGE OVARIAN; RANDOMIZED PHASE-III; PRIMARY CYTOREDUCTIVE SURGERY; PERITONEAL SURFACE COMPONENT; CARBOPLATIN PLUS PACLITAXEL; GYNECOLOGIC-ONCOLOGY-GROUP; PRIMARY DEBULKING SURGERY; NEOADJUVANT CHEMOTHERAPY;

D O I：

10.1016/j.hoc.2018.07.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epithelial ovarian cancer classically presents with vague persistent gastrointestinal, urologic, or nonacute abdominal/pelvic symptoms (bloating, early satiety, discomfort). Ultimately, a pelvic examination or imaging identifies an adnexal mass typically with accompanied advanced peritoneal dissemination. Management involves aggressive cytoreductive surgery in combination with platinum and taxane chemotherapy. Over the last 20 years, optimal resection and mode and timing of chemotherapy have evolved. The authors review the initial diagnosis and management and present the available data and recommendations to guide the decision tree of when to use neoadjuvant, intraperitoneal, HIPEC, dose-dense, and maintenance chemotherapy in the front-line treatment of epithelial ovarian cancer.

引用

页码：943 / +

页数：23

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