8-methyl-pyridoxatin:: A novel N-hydroxy pyridone from fungus OS-F61800 that induces erythropoietin in human cells

被引：21
作者：
Cai, P
Smith, D
Cunningham, B
Brown-Shimer, S
Katz, B
Pearce, C
Venables, D
Houck, D
机构：
[1] MYCOsearch, Durham, NC 27707 USA
[2] OSI Pharmaceut, Uniondale, NY 11553 USA
[3] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA
[4] Oncogene Sci Diagnost, Cambridge, MA 02142 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 02期
关键词：
D O I：
10.1021/np980450t
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
In the course of screening for small-molecule modulators of erythropoietin gene expression, a novel N-hydroxy pyridone was isolated from a culture of OS-F61800. Its structure was elucidated by extensive H-1 and C-13 NMR spectroscopic and chemical studies. This compound induced erythropoietin gene expression fivefold at a concentration of 0.3 mu M, which is about threefold greater potency than our previously identified erythropoietin inducers.
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页码：397 / 399
页数：3
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