A Single Phosphine Ligand Allows Palladium-Catalyzed Intermolecular C-O Bond Formation with Secondary and Primary Alcohols

被引：181

作者：

Wu, Xiaoxing ^{[1
]}

Fors, Brett P. ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 42期

基金：

美国国家卫生研究院;

关键词：

arenes; C-O cross-coupling; ligand design; palladium; synthetic methods; UNACTIVATED ARYL HALIDES; ALIPHATIC-ALCOHOLS; COUPLING REACTIONS; REDUCTIVE ELIMINATION; OXYGEN HETEROCYCLES; EFFICIENT CATALYST; DIARYL ETHERS; BUTYL ETHERS; CHLORIDES; CONVERSION;

D O I：

10.1002/anie.201104361

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Forging a bond: An efficient, general palladium catalyst for C-O bond-forming reactions of secondary and primary alcohols with a range of aryl halides has been developed using the ligand 1. Heteroaryl halides, and for the first time, electron-rich aryl halides can be coupled with secondary alcohols. A diverse set of substrate combinations are possible with just a single ligand, thus obviating the need to survey multiple ligands. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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收藏

页码：9943 / 9947

页数：5

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