Recent progress in continuous manufacturing of oral solid dosage forms

被引：85
|
作者：
Vanhoorne, V. [1 ]
Vervaet, C. [1 ]
机构：
[1] Univ Ghent, Lab Pharmaceut Technol, Ottergemsesteenweg 460, B-9000 Ghent, Belgium
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2020年 / 579卷
关键词：
Continuous manufacturing; Twin-screw granulation; Roller compaction; Direct compression; Advanced process control; Process analytical technology; CONTINUOUS DIRECT COMPRESSION; NEAR-INFRARED SPECTROSCOPY; TWIN-SCREW GRANULATION; PROCESS ANALYTICAL TECHNOLOGY; CRITICAL QUALITY ATTRIBUTES; IN-LINE; WET GRANULATION; RAW-MATERIALS; DRUG CONTENT; PHARMACEUTICAL TABLETS;
D O I：
10.1016/j.ijpharm.2020.119194
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Continuous drug product manufacturing is slowly being implemented in the pharmaceutical industry. Although the benefits related to the quality and cost of continuous manufacturing are widely recognized, several challenges hampered the widespread introduction of continuous manufacturing of drug products. Current review presents an overview of state-of-the art research, equipment, process analytical technology implementations and advanced control strategies. Additionally, guidelines and regulatory viewpoints on implementation of continuous manufacturing in the pharmaceutical industry are discussed.
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页数：16
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