Dynamic Ligand Exchange as a Mechanistic Probe in Pd-Catalyzed Enantioselective C-H Functionalization Reactions Using Monoprotected Amino Acid Ligands

被引：14

作者：

Hill, David E. ^{[1
]}

Bay, Katherine L. ^{[2
]}

Yang, Yun-Fang ^{[2
]}

Plata, R. Erik ^{[1
]}

Takise, Ryosuke ^{[3
]}

Houk, K. N. ^{[2
]}

Yu, Jin-Quan ^{[1
]}

Blackmond, Donna G. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[3] Nagoya Univ, Inst Transformat Biomol WPI ITbM, Nagoya, Aichi 4648602, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2017年 / 139卷 / 51期

基金：

美国国家科学基金会;

关键词：

ACTIVATION; IODINATION;

D O I：

10.1021/jacs.7b11962

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new tool for probing enantioselective reaction mechanisms is introduced. Monitoring the temporal change in product enantiomeric excess after addition of the opposite enantiomer of the ligand during the reaction provides a means of probing dynamic ligand exchange in enantioselective C-H iodination catalyzed by Pd with monoprotected amino acid ligands (MPAAs). This work has general potential to provide insights about the dynamics of catalyst and ligand molecularity and exchange.

引用

收藏

页码：18500 / 18503

页数：4

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