Individual analysis of EEG frequency and band power in mild Alzheimer's disease

被引:272
作者
Moretti, DV
Babiloni, C
Binetti, G
Cassetta, E
Dal Forno, G
Ferreric, F
Ferri, R
Lanuzza, B
Miniussi, C
Nobili, F
Rodriguez, G
Salinari, S
Rossini, PM
机构
[1] Univ Roma La Sapienza, Dipartimento Fisiol Umana & Farmacol, I-00185 Rome, Italy
[2] IRCCS S Giovanni Dio FBF, Brescia, Italy
[3] AFaR Osped FBF, Rome, Italy
[4] IRCCS, Oasi Inst Res Mental Retardat & Brain Aging, Dept Neurol, Turin, Italy
[5] Univ Genoa, DIMI, Div Clin Neurophysiol, I-16126 Genoa, Italy
[6] Univ Roma La Sapienza, Dipartimento Informat & Sistemist, Rome, Italy
[7] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21218 USA
关键词
mild Alzheimer's disease; vascular dementia; electroencephalography; alpha rhythm; delta rhythm;
D O I
10.1016/S1388-2457(03)00345-6
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: This EEG study investigates the role of the cholinergic system, cortico-cortical connections, and sub-cortical white matter on the relationship between individual EEG frequencies and their relative power bands. Methods: EEGs were recorded at rest in 30 normal elderly subjects (Nold), 60 mild Alzheimer disease (AD) and 20 vascular dementia (VaD) patients, comparable for Mini Mental State Evaluation scores (MMSE 17-24). Individual EEG frequencies were indexed by the theta/alpha transition frequency (TF) and by the individual alpha frequency (IAF) with power peak in the extended alpha range (5-14 Hz). Relative power was separately computed for delta, theta, alphal, alpha2, and alpha3 bands, on the basis of the TF and IAF. Results: Using normal subjects as a reference, VaD patients showed 'slowing' of alpha frequency (TF-IAF) and lower alpha2 power; Mild AD patients showed lower alpha2 and alpha3 power; delta power was higher in both AD and VaD patients; Theta power was higher only in VaD patients. Conclusions: Individual analysis of the alpha frequency and power can discriminate mild AD from VaD and normal elderly subjects. Significance: This analysis may probe pathophysiological mechanisms causing AD and VaD. (C) 2003 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:299 / 308
页数:10
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