Plasma cholinesterase levels and health symptoms in peruvian farm workers exposed to organophosphate pesticides

被引:47
作者
Catano, Hector C. [2 ]
Carranza, Elizabeth [3 ]
Huamani, Carlos [4 ]
Hernandez, Antonio F. [1 ]
机构
[1] Univ Granada, Sch Med, Dept Legal Med & Toxicol, E-18071 Granada, Spain
[2] Univ Nacl Mayor San Marcos, Mol Biol Lab, Inst Quim Biol Microbiol & Biotecnol, Fac Farm & Bioquim, Lima 1, Peru
[3] Univ Nacl Mayor San Marcos, Hosp Loayza, Lab Bioquim, Inst Nacl Biol Andina,Fac Med, Lima 14, Peru
[4] INS, CENSOPAS, Direcc Ejecut Prevent & Control Riesgos Occupac &, Lima, Peru
关键词
D O I
10.1007/s00244-007-9095-0
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The purpose of this study was to examine plasma cholinesterase (PChE) changes and the adverse health effects associated with chronic low-dose exposure to organophosphates (OPs) in a Peruvian agricultural population. A cross-sectional study with a clinical interview and blood tests was performed among 213 farm workers from two subtropical valleys in Peru. The control group consisted of 78 nonexposed workers from the same areas. PChE levels from the two exposed subgroups (pesticide applicators and other agricultural jobs) were significantly lower than those of controls (1554 +/- 315 U/l, 1532 +/- 340 U/l, and 1787 +/- 275 U/l, respectively). Fifteen percent of the exposed population reported a past poisoning by pesticides, all of them needing medical evaluation and treatment. They had significantly lower PChE levels as compared to those without this antecedent. Approximately 61% of the exposed workers reported pesticide-related symptoms, but no significant difference was found in their PChE as compared to workers without symptoms. On the other hand, the use of personal protective equipment (PPE) was significantly associated with higher PChE levels and with a lower risk of reporting pesticide-related symptoms, which supports the benefit from using appropriate protective measures. In conclusion, data indicate that farm workers exposed to OPs in developing countries need to be monitored by means of PChE and an examination of their clinical status, which would allow identification of farm workers most at risk from pesticide toxicity. The use of correct PPE is highly recommended.
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页码:153 / 159
页数:7
相关论文
共 31 条
[1]   Regulating and assessing risks of cholinesterase-inhibiting pesticides: Divergent approaches and interpretations [J].
Carlock, LL ;
Chen, WL ;
Cordon, EB ;
Killeen, JC ;
Manley, A ;
Meyer, LS ;
Mullin, LS ;
Pendino, KJ ;
Percy, A ;
Sargent, DE ;
Seaman, LR ;
Svanborg, NK ;
Stanton, RH ;
Van Goethem, IL .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, 1999, 2 (02) :105-160
[2]   PESTICIDE EXPOSURES, CHOLINESTERASE DEPRESSION, AND SYMPTOMS AMONG NORTH-CAROLINA MIGRANT FARMWORKERS [J].
CIESIELSKI, S ;
LOOMIS, DP ;
MIMS, SR ;
AUER, A .
AMERICAN JOURNAL OF PUBLIC HEALTH, 1994, 84 (03) :446-451
[3]   Expert panel report of human studies on chlorpyrifos and or other organophosphate exposures [J].
Clegg, DJ ;
van Gemert, M .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, 1999, 2 (03) :257-279
[4]  
Cole DC, 1998, J TOXICOL ENV HEAL A, V55, P77, DOI 10.1080/009841098158520
[5]   BIOLOGICAL MONITORING OF AGRICULTURAL-WORKERS EXPOSED TO PESTICIDES .1. CHOLINESTERASE ACTIVITY DETERMINATIONS [J].
COYE, MJ ;
LOWE, JA ;
MADDY, KT .
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 1986, 28 (08) :619-627
[6]  
Cucuianu M, 2002, Rom J Intern Med, V40, P43
[7]   Peripheral cholinesterase inhibition by occupational chlorpyrifos exposure in Australian termiticide applicators [J].
Dyer, SM ;
Cattani, M ;
Pisaniello, DL ;
Williams, FM ;
Edwards, JW .
TOXICOLOGY, 2001, 169 (03) :177-185
[8]   A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].
ELLMAN, GL ;
COURTNEY, KD ;
ANDRES, V ;
FEATHERSTONE, RM .
BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&
[9]   Morbidity among farm workers in a desert country in relation to long-term exposure to pesticides [J].
Gomes, J ;
Lloyd, O ;
Revitt, MD ;
Basha, M .
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, 1998, 24 (03) :213-219
[10]   Changes in erythrocyte enzymes in humans long-term exposed to pesticides -: Influence of several markers of individual susceptibility [J].
Hernández, AF ;
López, O ;
Rodrigo, L ;
Gil, F ;
Pena, G ;
Serrano, JL ;
Parrón, T ;
Alvarez, JC ;
Lorente, JA ;
Pla, A .
TOXICOLOGY LETTERS, 2005, 159 (01) :13-21