Contribution of mutation at amino acid 45 of AcrR to acrB expression and ciprofloxacin resistance in clinical and veterinary Escherichia coli isolates

被引：57

作者：

Webber, MA ^{[1
]}

Talukder, A ^{[1
]}

Piddock, LJV ^{[1
]}

机构：

[1] Univ Birmingham, Antimicrobial Agents Res Grp, Div Immun & Infect, Birmingham B15 2TT, W Midlands, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 10期

关键词：

D O I：

10.1128/AAC.49.10.4390-4392.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fluoroquinolone-resistant Escherichia coli isolates which overexpressed acrB and had a substitution at amino acid 45 of AcrR were complemented with wild-type acrR. Complementation led to increased sensitivity to ciprofloxacin and to ethidium bromide, suggesting that mutation at amino acid 45 of AcrR contributes to ciprofloxacin resistance.

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页码：4390 / 4392

页数：3

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