Underweight and Weight Change Increases End-Stage Renal Disease Risk in Patients with Diabetes: A Nationwide Population-Based Cohort Study

被引：10

作者：

Bae, Eun Hui ^{[1
,2
]}

Oh, Tae Ryom ^{[1
,2
]}

Suh, Sang Heon ^{[1
,2
]}

Yang, Eun Mi ^{[1
,2
]}

Choi, Hong Sang ^{[1
,2
]}

Kim, Chang Seong ^{[1
,2
]}

Ma, Seong Kwon ^{[1
,2
]}

Kim, Bongseong ^{[3
]}

Han, Kyung-Do ^{[3
]}

Kim, Soo Wan ^{[1
,2
]}

机构：

[1] Chonnam Natl Univ, Med Sch, Dept Internal Med, 42 Jebongro, Gwangju 61469, South Korea

[2] Chonnam Natl Univ Hosp, Dept Internal Med, 42 Jebongro, Gwangju 61469, South Korea

[3] Soongsil Univ, Dept Stat & Actuarial Sci, 369 Sangdo Ro, Seoul 06978, South Korea

来源：

NUTRIENTS | 2022年 / 14卷 / 01期

关键词：

weight change; end-stage renal disease; diabetes; body mass index; waist circumference; national health programs; BODY-MASS INDEX; CHRONIC KIDNEY-DISEASE; OBESITY; OUTCOMES; ASSOCIATION; VARIABILITY; ONSET;

D O I：

10.3390/nu14010154

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Weight variability has known as a risk factor for cardiovascular events and mortality. However, its effect on end-stage renal disease (ESRD) development remains controversial. We investigated the relationship between weight change and ESRD risk. Overall, 97,029 patients with DM aged >20 years were selected from the Korean National Health Screening Program 2009-2012. Weight change was defined as differences in body weight from the index year to 2 years later. Newly diagnosed ESRD was observed until 2017 end. Over a 5.1-year median follow-up period, ESRD was newly diagnosed in 7932 (4.81%) DM patients. BMI < 18.5 kg/m(2) and waist circumferences 100/95 cm were ESRD risk factors. ESRD risk increased with increasing weight change; >= 10% weight loss (hazard ratio [HR], 1.247) followed by >= 10% weight gain (1.247) was associated with a higher HR than <= 5% weight change after adjusting for several confounding factors. The association between weight change and ESRD risk in a subgroup analysis was significantly stronger in patients aged <65 years, without proteinuria, with BMI >= 25, with DM duration <5 years, and prescribed less than 3 classes of DM medication. Underweight patients showed higher ESRD risks than overweight patients. Weight loss >10% was associated with the fastest decline in renal function.

引用

页数：13

共 32 条

[1] Association of Body Mass Index with Clinical Outcomes in Non-Dialysis-Dependent Chronic Kidney Disease: A Systematic Review and Meta-Analysis [J].