Clinical severity and quality of life in children and adolescents with Rett syndrome

被引:62
作者
Lane, J. B. [1 ]
Lee, H-S. [2 ]
Smith, L. W. [2 ]
Cheng, P. [2 ]
Percy, A. K. [1 ]
Glaze, D. G. [3 ]
Neul, J. L. [3 ]
Motil, K. J. [3 ]
Barrish, J. O. [3 ]
Skinner, S. A. [4 ]
Annese, F. [4 ]
McNair, L. [4 ]
Graham, J. [4 ]
Khwaja, O. [5 ]
Barnes, K. [5 ]
Krischer, J. P.
机构
[1] Univ Alabama Birmingham, Civitan Int Res Ctr, Birmingham, AL USA
[2] Univ S Florida, Dept Pediat, Tampa, FL 33620 USA
[3] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA
[4] Greenwood Genet Ctr, Greenwood, SC 29646 USA
[5] Childrens Hosp, Dept Neurol, Boston, MA 02115 USA
关键词
HEALTH; MUTATIONS;
D O I
10.1212/WNL.0b013e3182377dd2
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: The clinical features and genetics of Rett syndrome (RTT) have been well studied, but examination of quality of life (QOL) is limited. This study describes the impact of clinical severity on QOL among female children and adolescents with classic RTT. Methods: Cross-sectional and longitudinal analyses were conducted on data collected from an NIH-sponsored RTT natural history study. More than 200 participants from 5 to 18 years of age with classic RTT finished their 2-year follow-up at the time of analysis. Regression models after adjustment for their MECP2 mutation type and age at enrollment were used to examine the association between clinical status and QOL. Results: Severe clinical impairment was highly associated with poor physical QOL, but worse motor function and earlier age at onset of RTT stereotypies were associated with better psychosocial QOL; conversely, better motor function was associated with poorer psychosocial QOL. Conclusions: Standard psychosocial QOL assessment for children and adolescents with RTT differs significantly with regard to their motor function severity. As clinical trials in RTT emerge, the Child Health Questionnaire 50 may represent one of the important outcome measures. Neurology (R) 2011;77:1812-1818
引用
收藏
页码:1812 / 1818
页数:7
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