Acute toxicity and withdrawal syndromes related to gamma-hydroxybutyrate (GHB) and its analogues gamma-butyrolactone (GBL) and 1,4-butanediol(1,4-BD)1

被引：64

作者：

Wood, David M. ^{[1
,2
]}

Brailsford, Alan D. ^{[3
]}

Dargan, Paul I. ^{[1
,2
]}

机构：

[1] Guys & St Thomas NHS Fdn Trust, London, England

[2] Kings Hlth Partners London, London, England

[3] Kings Coll London, Drug Control Ctr, London WC2R 2LS, England

来源：

DRUG TESTING AND ANALYSIS | 2011年 / 3卷 / 7-8期

关键词：

gamma-hydroxybutyrate; gamma-butyrolactone; 1,4-butanediol; poisoning; recreational drugs; drugs of abuse; dependency; withdrawal; IN-VITRO PRODUCTION; CHROMATOGRAPHY-MASS SPECTROMETRY; ACID GHB; RAT-BRAIN; CAPILLARY-ELECTROPHORESIS; URINARY CONCENTRATIONS; PHYSICAL-DEPENDENCE; CLINICAL-FEATURES; POSTMORTEM BLOOD; ANTEMORTEM URINE;

D O I：

10.1002/dta.292

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Gamma-hydroxybutyrate (GHB) has been used as a recreational drug since the 1990s and over the last few years there has been increasing use of its analogues gamma-butyrolactone (GBL) and to a lesser extent 1,4-butanediol (1,4BD). This review will summarize the literature on the pharmacology of these compounds; the patterns and management of acute toxicity associated with their use; and the clinical patterns of presentation and management of chronic dependency associated with GHB and its analogues. Copyright (C) 2011 John Wiley & Sons, Ltd.

引用

页码：417 / 425

页数：9

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