Lyme Disease and Associated NMDAR Encephalitis: A Case Report and Literature Review

被引：4
作者：
Predkele, Natalja [1 ,2 ,3 ]
Mednieks, Janis [1 ,2 ]
机构：
[1] Paul Stradins Clin Univ Hosp, Dept Neurol, 13 Pilsonu St, LV-1002 Riga, Latvia
[2] Riga Stradins Univ, Dept Neurol & Neurosurg, 16 Dzirciema St, LV-1007 Riga, Latvia
[3] Riga Stradins Univ, Fac Residency, 16 Dzirciema St, LV-1007 Riga, Latvia
来源：
NEUROLOGY INTERNATIONAL | 2021年 / 13卷 / 04期
关键词：
Lyme disease; neuroborreliosis; autoimmune encephalitis; NMDAR antibodies; NMDAR encephalitis; ASPARTATE RECEPTOR ENCEPHALITIS; DIAGNOSIS; PATHOGENESIS; BORRELIOSIS; INFECTION;
D O I：
10.3390/neurolint13040048
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We present a case of a patient with positive N-methyl-D-aspartate receptor (NMDAR) IgG antibodies in their serum and cerebrospinal fluid (CSF) associated with neuroborreliosis. Clinically, the patient presented with symptoms of confusion, as well as behavioral and speech impairments. Regardless of antibacterial treatment, no significant improvement was achieved. Methylprednisolone provided a marked improvement in the patient's clinical signs and CSF findings. The screening did not reveal any underlying neoplasm. Taking into account the marked clinical improvement after treatment with glucocorticosteroids, we suggest that NMDAR encephalitis is a possible autoimmune complication in neuroborreliosis patients requiring additional immunotherapy.
引用
收藏
页码：487 / 496
页数：10
相关论文
共 42 条
[1]   Are Anti-Retinal Autoantibodies a Cause or a Consequence of Retinal Degeneration in Autoimmune Retinopathies? [J].
Adamus, Grazyna .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[2]   Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis [J].
Armangue, Thais ;
Spatola, Marianna ;
Vlagea, Alexandru ;
Mattozzi, Simone ;
Carceles-Cordon, Marc ;
Martinez-Heras, Eloy ;
Llufriu, Sara ;
Muchart, Jordi ;
Elena Erro, Maria ;
Abraira, Laura ;
Moris, German ;
Monros-Gimenez, Luis ;
Corral-Corral, Inigo ;
Montejo, Carmen ;
Toledo, Manuel ;
Bataller, Luis ;
Secondi, Gabriela ;
Arino, Helena ;
Martinez-Hernandez, Eugenia ;
Juan, Manel ;
Angeles Marcos, Maria ;
Alsina, Laia ;
Saiz, Albert ;
Rosenfeld, Myrna R. ;
Graus, Francesc ;
Dalmau, Josep .
LANCET NEUROLOGY, 2018, 17 (09) :760-772
[3]   The Positive Predictive Value of Onconeural Antibody Testing: A Retrospective Review [J].
Budhram, Adrian ;
Nicolle, Michael W. ;
Yang, Liju .
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2018, 45 (05) :577-579
[4]   Lyme Neuroborreliosis: Clinical Outcomes, Controversy, Pathogenesis, and Polymicrobial Infections [J].
Carlos Garcia-Monco, Juan ;
Benach, Jorge L. .
ANNALS OF NEUROLOGY, 2019, 85 (01) :21-31
[5]   Anti-NMDAR encephalitis preceded by non-herpetic central nervous system infection: Systematic literature review and first case of tick-borne encephalitis triggering anti-NMDAR encephalitis [J].
Cavaliere, Elena ;
Nosadini, Margherita ;
Pelizza, Maria Federica ;
Ventura, Giulia ;
Toldo, Irene ;
Sartori, Stefano .
JOURNAL OF NEUROIMMUNOLOGY, 2019, 332 :1-7
[6]   Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma [J].
Dalmau, Josep ;
Tuzun, Erdem ;
Wu, Hai-yan ;
Masjuan, Jaime ;
Rossi, Jeffrey E. ;
Voloschin, Alfredo ;
Baehring, Joachim M. ;
Shimazaki, Haruo ;
Koide, Rej ;
King, Dale ;
Mason, Warren ;
Sansing, Lauren H. ;
Dichter, Marc A. ;
Rosenfeld, Myrna R. ;
Lynch, David R. .
ANNALS OF NEUROLOGY, 2007, 61 (01) :25-36
[7]   An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models [J].
Dalmau, Josep ;
Armangue, Thais ;
Planaguma, Jesus ;
Radosevic, Ma ;
Mannara, Francesco ;
Leypoldt, Frank ;
Geis, Christian ;
Lancaster, Eric ;
Titulaer, Maarten J. ;
Rosenfeld, Myrna R. ;
Graus, Francesc .
LANCET NEUROLOGY, 2019, 18 (11) :1045-1057
[8]   AUTOANTIBODIES TO SYNAPTIC RECEPTORS AND NEURONAL CELL SURFACE PROTEINS IN AUTOIMMUNE DISEASES OF THE CENTRAL NERVOUS SYSTEM [J].
Dalmau, Josep ;
Geis, Christian ;
Graus, Francesc .
PHYSIOLOGICAL REVIEWS, 2017, 97 (02) :839-887
[9]   NMDA receptor encephalitis and other antibody-mediated disorders of the synapse The 2016 Cotzias Lecture [J].
Dalmau, Josep .
NEUROLOGY, 2016, 87 (23) :2471-2482
[10]   Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis [J].
Dalmau, Josep ;
Lancaster, Eric ;
Martinez-Hernandez, Eugenia ;
Rosenfeld, Myrna R. ;
Balice-Gordon, Rita .
LANCET NEUROLOGY, 2011, 10 (01) :63-74
12345