Lyme Disease and Associated NMDAR Encephalitis: A Case Report and Literature Review

被引：4
作者：
Predkele, Natalja [1 ,2 ,3 ]
Mednieks, Janis [1 ,2 ]
机构：
[1] Paul Stradins Clin Univ Hosp, Dept Neurol, 13 Pilsonu St, LV-1002 Riga, Latvia
[2] Riga Stradins Univ, Dept Neurol & Neurosurg, 16 Dzirciema St, LV-1007 Riga, Latvia
[3] Riga Stradins Univ, Fac Residency, 16 Dzirciema St, LV-1007 Riga, Latvia
来源：
NEUROLOGY INTERNATIONAL | 2021年 / 13卷 / 04期
关键词：
Lyme disease; neuroborreliosis; autoimmune encephalitis; NMDAR antibodies; NMDAR encephalitis; ASPARTATE RECEPTOR ENCEPHALITIS; DIAGNOSIS; PATHOGENESIS; BORRELIOSIS; INFECTION;
D O I：
10.3390/neurolint13040048
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We present a case of a patient with positive N-methyl-D-aspartate receptor (NMDAR) IgG antibodies in their serum and cerebrospinal fluid (CSF) associated with neuroborreliosis. Clinically, the patient presented with symptoms of confusion, as well as behavioral and speech impairments. Regardless of antibacterial treatment, no significant improvement was achieved. Methylprednisolone provided a marked improvement in the patient's clinical signs and CSF findings. The screening did not reveal any underlying neoplasm. Taking into account the marked clinical improvement after treatment with glucocorticosteroids, we suggest that NMDAR encephalitis is a possible autoimmune complication in neuroborreliosis patients requiring additional immunotherapy.
引用
收藏
页码：487 / 496
页数：10
相关论文
共 42 条
  • [1] Are Anti-Retinal Autoantibodies a Cause or a Consequence of Retinal Degeneration in Autoimmune Retinopathies?
    Adamus, Grazyna
    [J]. FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [2] Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis
    Armangue, Thais
    Spatola, Marianna
    Vlagea, Alexandru
    Mattozzi, Simone
    Carceles-Cordon, Marc
    Martinez-Heras, Eloy
    Llufriu, Sara
    Muchart, Jordi
    Elena Erro, Maria
    Abraira, Laura
    Moris, German
    Monros-Gimenez, Luis
    Corral-Corral, Inigo
    Montejo, Carmen
    Toledo, Manuel
    Bataller, Luis
    Secondi, Gabriela
    Arino, Helena
    Martinez-Hernandez, Eugenia
    Juan, Manel
    Angeles Marcos, Maria
    Alsina, Laia
    Saiz, Albert
    Rosenfeld, Myrna R.
    Graus, Francesc
    Dalmau, Josep
    [J]. LANCET NEUROLOGY, 2018, 17 (09) : 760 - 772
  • [3] The Positive Predictive Value of Onconeural Antibody Testing: A Retrospective Review
    Budhram, Adrian
    Nicolle, Michael W.
    Yang, Liju
    [J]. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2018, 45 (05) : 577 - 579
  • [4] Lyme Neuroborreliosis: Clinical Outcomes, Controversy, Pathogenesis, and Polymicrobial Infections
    Carlos Garcia-Monco, Juan
    Benach, Jorge L.
    [J]. ANNALS OF NEUROLOGY, 2019, 85 (01) : 21 - 31
  • [5] Anti-NMDAR encephalitis preceded by non-herpetic central nervous system infection: Systematic literature review and first case of tick-borne encephalitis triggering anti-NMDAR encephalitis
    Cavaliere, Elena
    Nosadini, Margherita
    Pelizza, Maria Federica
    Ventura, Giulia
    Toldo, Irene
    Sartori, Stefano
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2019, 332 : 1 - 7
  • [6] Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma
    Dalmau, Josep
    Tuzun, Erdem
    Wu, Hai-yan
    Masjuan, Jaime
    Rossi, Jeffrey E.
    Voloschin, Alfredo
    Baehring, Joachim M.
    Shimazaki, Haruo
    Koide, Rej
    King, Dale
    Mason, Warren
    Sansing, Lauren H.
    Dichter, Marc A.
    Rosenfeld, Myrna R.
    Lynch, David R.
    [J]. ANNALS OF NEUROLOGY, 2007, 61 (01) : 25 - 36
  • [7] An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models
    Dalmau, Josep
    Armangue, Thais
    Planaguma, Jesus
    Radosevic, Ma
    Mannara, Francesco
    Leypoldt, Frank
    Geis, Christian
    Lancaster, Eric
    Titulaer, Maarten J.
    Rosenfeld, Myrna R.
    Graus, Francesc
    [J]. LANCET NEUROLOGY, 2019, 18 (11) : 1045 - 1057
  • [8] AUTOANTIBODIES TO SYNAPTIC RECEPTORS AND NEURONAL CELL SURFACE PROTEINS IN AUTOIMMUNE DISEASES OF THE CENTRAL NERVOUS SYSTEM
    Dalmau, Josep
    Geis, Christian
    Graus, Francesc
    [J]. PHYSIOLOGICAL REVIEWS, 2017, 97 (02) : 839 - 887
  • [9] NMDA receptor encephalitis and other antibody-mediated disorders of the synapse The 2016 Cotzias Lecture
    Dalmau, Josep
    [J]. NEUROLOGY, 2016, 87 (23) : 2471 - 2482
  • [10] Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis
    Dalmau, Josep
    Lancaster, Eric
    Martinez-Hernandez, Eugenia
    Rosenfeld, Myrna R.
    Balice-Gordon, Rita
    [J]. LANCET NEUROLOGY, 2011, 10 (01) : 63 - 74
12345