Synthesis and biological activity of analogues of ptilomycalin A

被引：24
作者：
Black, GP
Coles, SJ
Hizi, A
Howard-Jones, AG
Hursthouse, MB
McGown, AT
Loya, S
Moore, CG
Murphy, PJ [1 ]
Smith, NK
Walshe, NDA
机构：
[1] Univ Wales, Dept Chem, Bangor LL57 2UW, Gwynedd, Wales
[2] Pfizer Ltd, Cent Res, Sandwich CT13 9NJ, Kent, England
[3] Tel Aviv Univ, Sackler Sch Med, Dept Cell Biol & Histol, Tel Aviv, Israel
[4] Christie Hosp NHS Trust, Paterson Inst Canc Res, Christie CRC Res Ctr, Manchester M20 4BX, Lancs, England
[5] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 19期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1016/S0040-4039(01)00400-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Benzo-fused model compounds 21a and 21b, resembling in structure the marine metabolite ptilomycalin A, were prepared and were shown to display significant activity against a series of cancer cell lines and to also possess a significant activity against the DNA polymerase activity of the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT). (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3377 / 3381
页数：5
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