Endocrine gland-derived vascular endothelial growth factor concentrations in follicular fluid and serum may predict ovarian hyperstimulation syndrome in women undergoing controlled ovarian hyperstimulation

被引：20
|
作者：
Gao, Min-Zhi [1 ,2 ]
Zhao, Xiao-Ming [1 ]
Sun, Zhao-Gui [3 ]
Hong, Yan [1 ]
Zhao, Lei-Wen [1 ]
Zhang, Hui-Qin [2 ]
机构：
[1] Shanghai Jiao Tong Univ, Dept Reprod Med, Renji Hosp, Sch Med, Shanghai 200030, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Shanghai 200433, Peoples R China
[3] Shanghai Inst Planned Parenthood Res, Key Lab Contracept Drugs & Devices NPFPC, Shanghai, Peoples R China
来源：
FERTILITY AND STERILITY | 2011年 / 95卷 / 02期
关键词：
Endocrine gland-derived vascular endothelial growth factor; vascular endothelial growth factor; ovarian hyperstimulation syndrome; controlled ovarian hyperstimulation; ovarian response; CORPUS-LUTEUM; SYNDROME OHSS; FACTOR VEGF; IN-VIVO; EG-VEGF; EXPRESSION; PROKINETICINS; ANGIOGENESIS; RECEPTORS; BV8;
D O I：
10.1016/j.fertnstert.2010.09.044
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To assess the predictive value of endocrine gland-derived vascular endothelial growth factor (EG-VEGF) concentrations in follicular fluid (FF) and serum for ovarian hyperstimulation syndrome (OHSS) in patients undergoing controlled ovarian hyperstimulation. Design: Retrospective, case-control study. Setting: University hospital, IVF center. Patient(s): Seventeen women with OHSS and 61 controls. Intervention(s): None. Main Outcome Measure(s): FF and serum EG-VEGF and VEGF concentrations, IVF outcome. Result(s): FF and serum EG-VEGF concentrations showed a significant negative correlation with serum E-2 concentration on the day of hCG administration. FF, but not serum, VEGF concentrations also showed a significant negative correlation with serum E2 concentrations on hCG day. The FF EG-VEGF, FF VEGF, and serum EG-VEFG concentrations were significantly lower in the OHSS group than in the non-OHSS group. There was no significant difference in serum VEGF concentrations. Among FF and serum EG-VEGF and VEGF concentrations, only FF EG-VEGF concentrations were significantly lower in patients with moderate OHSS than in those with mild OHSS. Conclusion(s): FF and serum EG-VEGF concentrations may predict OHSS occurrence. Furthermore, FF EG-VEGF concentrations were significantly correlated with OHSS severity; thus, EG-VEGF appears to be more valuable than VEGF for predicting OHSS. (Fertil Steril(R) 2011;95:673-8. (C) 2011 by American Society for Reproductive Medicine.)
引用
收藏
页码：673 / 678
页数：6
相关论文
共 50 条
  • [31] Vascular endothelial growth factor antagonist reduces the early onset and the severity of ovarian hyperstimulation syndrome
    Jellad, S.
    Soyah, N.
    Basly, M.
    Chibani, M.
    Rachdi, R.
    HUMAN REPRODUCTION, 2019, 34 : 458 - 459
  • [32] Vascular endothelial growth factor antagonist reduces the early onset and the severity of ovarian hyperstimulation syndrome
    Jellad, S.
    Hassine, A. Haj
    Basly, M.
    Mrabet, A.
    Chibani, M.
    Rachdi, R.
    JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION, 2017, 46 (01): : 87 - 91
  • [33] Vascular endothelial growth factor production by circulating immune cells is elevated in ovarian hyperstimulation syndrome
    Kosaka, Kenzo
    Fujiwara, Hiroshi
    Yoshioka, Shinya
    Fujii, Shingo
    HUMAN REPRODUCTION, 2007, 22 (06) : 1647 - 1651
  • [34] Superoxide dismutase activity in human follicular fluid after controlled ovarian hyperstimulation in women undergoing in vitro fertilization
    Sabatini, L
    Wilson, C
    Lower, A
    Al-Shawaf, T
    Grudzinskas, JG
    FERTILITY AND STERILITY, 1999, 72 (06) : 1027 - 1034
  • [35] Follicular fluid lipid peroxidation levels in women with endometriosis during controlled ovarian hyperstimulation
    de Lima, Camila Bruna
    Cordeiro, Fernanda Bertuccez
    Camargo, Mariana
    Zylbersztejn, Daniel Suslik
    Cedenho, Agnaldo Pereira
    Bertolla, Ricardo Pimenta
    Lo Turco, Edson Guimaraes
    HUMAN FERTILITY, 2017, 20 (01) : 48 - 54
  • [36] Changes in vascular endothelial growth factor levels and the risk of ovarian hyperstimulation syndrome in women enrolled in an in vitro fertilization program
    Artini, PG
    Fasciani, A
    Monti, M
    Luisi, S
    D'Ambrogio, G
    Genazzani, AR
    FERTILITY AND STERILITY, 1998, 70 (03) : 560 - 564
  • [37] Lipid peroxidation and vitamin E in serum and follicular fluid of infertile women with endometriosis submitted to controlled ovarian hyperstimulation
    Petean, Carla Campos
    Gomes, Fernando Marcos
    Rosa e Silva, Julio Cesar
    Ferriani, Rui Alberto
    de Moura, Marcos Dias
    dos Reis, Rosana Maria
    de Albuquerque Salles Navarro, Paula Andrea
    REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA, 2007, 29 (06): : 303 - 309
  • [38] Vascular endothelial growth factor plasma levels correlate to the clinical picture in severe ovarian hyperstimulation syndrome
    Abramov, Y
    Barak, V
    Nisman, B
    Schenker, JG
    FERTILITY AND STERILITY, 1997, 67 (02) : 261 - 265
  • [39] Role of vascular endothelial cell growth factor (VEGF) and angiopoietins (ANGPTs) in ovarian hyperstimulation syndrome (OHSS)
    de Zuniga, I.
    Colaci, D.
    Sobral, F.
    Bisioli, C.
    Scotti, L.
    Abramovich, D.
    Tesone, M.
    Parborell, F.
    HUMAN REPRODUCTION, 2011, 26 : I91 - I91
  • [40] Progesterone regulates ovarian vascular endothelial growth factor (VEGF) production in the ovarian hyperstimulation syndrome (OHSS)-model rats.
    Ishikawa, K
    Ohba, T
    Okamura, Y
    Tanaka, N
    Matsuura, K
    Okamura, H
    BIOLOGY OF REPRODUCTION, 2000, 62 : 177 - 177
12345