Estimation of effective reproduction numbers for infectious diseases using serological survey data

被引：40

作者：

Farrington, CP ^{[1
]}

Whitaker, HJ ^{[1
]}

机构：

[1] Open Univ, Dept Stat, Milton Keynes MK7 6AA, Bucks, England

来源：

BIOSTATISTICS | 2003年 / 4卷 / 04期

关键词：

eigenvalue; frailty; infectious disease; reproduction number; vaccine;

D O I：

10.1093/biostatistics/4.4.621

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effective reproduction number of an infection, denoted R-e, may be used to monitor the impact of a vaccination programme. If R-e is maintained below 1, then sustained endemic transmission of the infection cannot occur. In this paper we discuss methods for estimating R-e from serological survey data, allowing for age and individual heterogeneity. We describe semi-parametric and parametric models, and obtain an upper bound on R-e when vaccine coverage and efficacy are not known. The methods are illustrated using data on mumps and rubella in England and Wales.

引用

页码：621 / 632

页数：12

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