Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis

被引：6
作者：
Chen, Yong [1 ,2 ]
Xie, Chao Lian [1 ,2 ]
Hu, Ran [1 ,2 ]
Shen, Cheng Yi [1 ,3 ]
Zeng, Mei [4 ]
Wu, Chang Qiang [5 ]
Chen, Tian Wu [1 ,2 ]
Chen, Chen [1 ,2 ]
Tang, Meng Yue [1 ,2 ]
Xue, Hua Dan [6 ]
Jin, Zheng Yu [6 ]
Zhang, Xiao Ming [1 ,2 ]
机构：
[1] North Sichuan Med Coll, Affiliated Hosp, Sichuan Key Lab Med Imaging, Nanchong, Peoples R China
[2] North Sichuan Med Coll, Affiliated Hosp, Dept Radiol, Nanchong, Peoples R China
[3] North Sichuan Med Coll, Affiliated Hosp, Dept Pathophysiol, Nanchong, Peoples R China
[4] North Sichuan Med Coll, Biol Grp, Nanchong, Peoples R China
[5] North Sichuan Med Coll, Sichuan Key Lab Med Imaging, Nanchong, Peoples R China
[6] Chinese Acad Med Sci, Radiol Dept, Peking Union Med Coll Hosp, Beijing, Peoples R China
来源：
GASTROENTEROLOGY RESEARCH AND PRACTICE | 2017年 / 2017卷
关键词：
MIGRATION INHIBITORY FACTOR; TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE; MYOSIN IXB; ASSOCIATION; SPINK1; RISK; SUSCEPTIBILITY; VARIANTS; MUTATIONS;
D O I：
10.1155/2017/5135172
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Acute pancreatitis (AP) is a complex disease that results in significant morbidity and mortality. For many decades, it has compelled researchers to explore the exact pathogenesis and the understanding of the pathogenesis of AP has progressed dramatically. Currently, premature trypsinogen activation and NF-kappa B activation for inflammation are two remarkable hypotheses for the mechanism of AP. Meanwhile, understanding of the influence of genetic polymorphisms has resulted in tremendous development in the understanding of the advancement of complex diseases. Now, genetic polymorphisms of AP have been noted gradually and many researchers devote themselves to this emerging area. In this review, we comprehensively describe genetic polymorphisms combined with the latest hypothesis of pathogenesis associated with AP.
引用
收藏
页数：10
相关论文
共 83 条
  • [31] CD14, new aspects of ligand and signal diversity
    Landmann, R
    Müller, B
    Zimmerli, W
    [J]. MICROBES AND INFECTION, 2000, 2 (03) : 295 - 304
  • [32] Functional Effect of Polymorphisms in the Promoter of TNFAIP3 (A20) in Acute Pancreatitis in the Han Chinese Population
    Liu, Yugang
    Dan, Gang
    Wu, Lijuan
    Chen, Guangyu
    Wu, Ailin
    Zeng, Ping
    Xu, Wanqing
    [J]. PLOS ONE, 2014, 9 (07):
  • [33] Makhija R, 2007, J PANCREAS, V8, P289
  • [34] Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis
    Mareninova, Olga A.
    Hermann, Kip
    French, Samuel W.
    O'Konski, Mark S.
    Pandol, Stephen J.
    Webster, Paul
    Erickson, Ann H.
    Katunuma, Nobuhiko
    Gorelick, Fred S.
    Gukovsky, Ilya
    Gukovskaya, Anna S.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (11) : 3340 - 3355
  • [35] Genetic Susceptibility in Acute Pancreatitis Genotyping of GSTM1, GSTT1, GSTP1, CASP7, CASP8, CASP9, CASP10, LTA, TNFRSF1B, and TP53 Gene Variants
    Martins, Francisco d'Oliveira
    Gomes, Bruno Costa
    Rodrigues, Antonio Sebastiao
    Rueff, Jose
    [J]. PANCREAS, 2017, 46 (01) : 71 - 76
  • [36] -651C/T promoter polymorphism in the CD14 gene is associated with severity of acute pancreatitis in Japan
    Masamune, Atsushi
    Kume, Kiyoshi
    Kikuta, Kazuhiro
    Watanabe, Takashi
    Hirota, Morihisa
    Satoh, Kennichi
    Kanno, Atsushi
    Suzuki, Noriaki
    Kakuta, Yoichi
    Shimosegawa, Tooru
    [J]. JOURNAL OF GASTROENTEROLOGY, 2010, 45 (02) : 225 - 233
  • [37] Matas-Cobos AM, 2015, PANCREAS, V44, P429, DOI 10.1097/MPA.0000000000000272
  • [38] Gastric colonisation, intestinal permeability and septic morbidity in acute pancreatitis
    McNaught, CE
    Woodcock, NP
    Mitchell, CJ
    Rowley, G
    Johnstone, D
    MacFie, J
    [J]. PANCREATOLOGY, 2002, 2 (05) : 463 - 468
  • [39] Idiopathic chronic pancreatitis in India: phenotypic characterisation and strong genetic susceptibility due to SPINK1 and CFTR gene mutations
    Midha, Shallu
    Khajuria, Rajni
    Shastri, Shivaram
    Kabra, Madhulika
    Garg, Pramod Kumar
    [J]. GUT, 2010, 59 (06) : 800 - 807
  • [40] Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect
    Monsuur, AJ
    de Bakker, PIW
    Alizadeh, BZ
    Zhernakova, A
    Bevova, MR
    Strengman, E
    Franke, L
    van't Slot, R
    van Belzen, MJ
    Lavrijsen, ICM
    Diosdado, B
    Daly, MJ
    Mulder, CJJ
    Mearin, ML
    Meijer, JWR
    Meijer, GA
    van Oort, E
    Wapenaar, MC
    Koeleman, BPC
    Wijmenga, C
    [J]. NATURE GENETICS, 2005, 37 (12) : 1341 - 1344
123456789