Flavonoids from Chinese Viscum coloratum produce cytoprotective effects against ischemic myocardial injuries:: Inhibitory effect of flavonoids on PAF-induced Ca2+ overload

被引：14

作者：

Chu, Wenfeng ^{[2
]}

Qiao, Guofen ^{[2
]}

Bai, Yunlong ^{[2
]}

Pan, Zhenwei ^{[2
]}

Li, Guoyu ^{[2
]}

Piao, Xianmei ^{[2
]}

Wu, Ling ^{[2
]}

Lu, Yanjie ^{[2
]}

Yang, Baofeng ^{[1
]}

机构：

[1] Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China

[2] Incubator State Key Lab, Biopharmaceut Key Lab Heilongjiang Province, Harbin 150081, Peoples R China

来源：

PHYTOTHERAPY RESEARCH | 2008年 / 22卷 / 01期

关键词：

Viscum coloratum; PAF; Ca2+; ischemia; BN52021;

D O I：

10.1002/ptr.2267

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Viscum coloratum has been used in the indigenous system of medicine for the treatment of various diseases such as myocardial ischemia and arrhythmia. Platelet-activating factor (PAF) is an important player in cardiovascular diseases. The aim of this study was to investigate the protective effects of Viscum coloratum flavonoids (VCF) against ischemic myocardial injuries in vivo and to further investigate its regulatory effect on PAF. Studies were performed in a rat model of myocardial infarction and in isolated myocytes. It was found that VCF relieved myocardial injuries during ischemia. PAF (10(-11) m) significantly increased the intracellular free Ca2+ concentration ([Ca2+](i)) and VCF inhibited the changes induced by PAF in single cardiac myocytes. The results suggest that VCF can improve cardiac function and that VCF reduces ischemic myocardial injuries via blocking the signaling pathway of PAF. Therefore, PAF blockers may be candidate drugs for preventing cardiac injuries during ischemia/reperfusion, and subsequently improving cardiac function. Copyright (C) 2007 John Wiley & Sons, Ltd.

引用

页码：134 / 137

页数：4

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