Efficient Singlet Oxygen Generation by Luminescent 2-(2′-Thienyl)Pyridyl Cyclometalated Platinum(II) Complexes and Their Calixarene Derivatives

被引：25

作者：

Lai, Siu-Wai ^{[1
,2
,3
]}

Liu, Ying ^{[4
]}

Zhang, Dong ^{[4
]}

Wang, Bin ^{[1
,2
,3
]}

Lok, Chun-Nam ^{[1
,2
,3
]}

Che, Chi-Ming ^{[1
,2
,3
]}

Selke, Matthias ^{[4
]}

机构：

[1] Univ Hong Kong, Inst Mol Technol Drug Discovery & Synth, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Inst Mol Technol Drug Discovery & Synth, Open Lab Chem Biol, Hong Kong, Hong Kong, Peoples R China

[3] Univ Hong Kong, HKU CAS Joint Lab New Mat, Hong Kong, Hong Kong, Peoples R China

[4] Calif State Univ Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90032 USA

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 2010年 / 86卷 / 06期

基金：

中国国家自然科学基金;

关键词：

PHOTOPHYSICAL PROPERTIES; ORGANOMETALLIC COMPLEXES; PHOTOOXIDATION; OXIDATION; DIOXYGEN; LIGANDS;

D O I：

10.1111/j.1751-1097.2010.00809.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Luminescent cyclometalated platinum(II) complexes, namely [Pt(Thpy)(PPh3)X]n+ (HThpy = 2-(2'-thienyl)pyridine; X = Cl- (1), n = 0; X = CH3CN (2), pyridine (3), n = 1) and [Pt(Thpy)(HThpy)Y]n+ (Y = Cl- (4), n = 0; Y = pyridine (5), n = 1), exhibit structured emission with peak maximum at similar to 556 and 598 nm in degassed acetonitrile and with emission quantum yield and lifetime of up to 0.38 and 26 mu s, respectively. These complexes are efficient photosensitizers of singlet oxygen with yields up to > 90%. Complex 5 exhibited photocytotoxicity towards cancer cells and fluorescence microscopic images of cells incubated with 5 reveal substantial uptake at the nucleus and mitochondria.

引用

页码：1414 / 1420

页数：7

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