Bromodomain 4: a cellular Swiss army knife

被引：94

作者：

Devaiah, Ballachanda N. ^{[1
]}

Gegonne, Anne ^{[1
]}

Singer, Dinah S. ^{[1
]}

机构：

[1] NCI, Expt Immunol Branch, NIH, Bldg 10, Bethesda, MD 20892 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2016年 / 100卷 / 04期

基金：

美国国家卫生研究院;

关键词：

BRD4; kinase; Pol II; acetyltransferase; nucleosome eviction; ACUTE MYELOID-LEUKEMIA; PROTEIN BRD4 BINDS; P-TEFB; TRANSCRIPTIONAL REGULATORS; ACETYLATED CHROMATIN; GENE-TRANSCRIPTION; SUPER-ENHANCERS; TERMINAL DOMAIN; BREAST-CANCER; S-PHASE;

D O I：

10.1189/jlb.2RI0616-250R

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bromodomain protein 4 (BRD4) is a transcriptional and epigenetic regulator that plays a pivotal role in cancer and inflammatory diseases. BRD4 binds and stays associated with chromatin during mitosis, bookmarking early G1 genes and reactivating transcription after mitotic silencing. BRD4 plays an important role in transcription, both as a passive scaffold via its recruitment of vital transcription factors and as an active kinase that phosphorylates RNA polymerase II, directly and indirectly regulating transcription. Through its HAT activity, BRD4 contributes to the maintenance of chromatin structure and nucleosome clearance. This review summarizes the known functions of BRD4 and proposes a model in which BRD4 actively coordinates chromatin structure and transcription.

引用

页码：679 / 686

页数：8

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