Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase

被引：39

作者：

Ye, Ying ^{[1
]}

Ozaki, Taro ^{[1
]}

Umemura, Myco ^{[2
,3
]}

Liu, Chengwei ^{[1
]}

Minami, Atsushi ^{[1
]}

Oikawa, Hideaki ^{[1
]}

机构：

[1] Hokkaido Univ, Fac Sci, Dept Chem, Sapporo, Hokkaido 0600810, Japan

[2] Natl Inst Adv Ind Sci & Technol, Bioprod Res Inst, Tsukuba, Ibaraki 3058566, Japan

[3] AIST, CBBD OIL, Tsukuba, Ibaraki 3058566, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 01期

关键词：

CONSTITUENT AMINO-ACIDS; PEPTIDE USTILOXIN B; NATURAL-PRODUCTS; ABSOLUTE-CONFIGURATION; MARFEYS METHOD; FAMILY; GENE; BIOSYNTHESIS; EXPRESSION; PATHWAY;

D O I：

10.1039/c8ob02824a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asperipin-2a is a ribosomally synthesized and post-translationally modified peptide isolated from Asperigillus flavus. Herein, we report the heterologous production of asperipin-2a and determination of its absolute structure. Notably, the characteristic bicyclic structure was likely constructed by a single oxidase containing the DUF3328 domain.

引用

页码：39 / 43

页数：5

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