Rhythmic pattern in pain and their chronotherapy

被引：81
作者：
Bruguerolle, Bernard
Labrecque, Gaston
机构：
[1] Fac Med Marseille, Lab Pharmacol Med & Clin, F-13385 Marseille 5, France
[2] Univ Laval, Fac Pharm, Quebec City, PQ G1K 7P4, Canada
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2007年 / 59卷 / 9-10期
关键词：
aspirin; chronokinetics; chronopharmacology; Chronotherapy; computer-controlled analgesia; drug-delivery modeling; local anesthetics; morphine; NSAIDs; Opioids; pain; paracetamol; placebo; tramadol; Transdermal systems;
D O I：
10.1016/j.addr.2006.06.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Pain control is one of the most important therapeutic priorities; nonetheless, inadequate pain relief remains a significant health care issue. Thus, it is important to determine whether the analgesic effect can be improved by using the chronopharmacological approach. This paper reviews the data on the rhythmic patterns in pain level and their chronotherapy. It underlines the major issues and problems related to the development of chronotherapeutic strategies, and it examines emerging aspects of new drug-delivery systems for achieving such. (c) 2007 Elsevier B.V All rights reserved.
引用
收藏
页码：883 / 895
页数：13
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