Simulations of lipid vesicle rupture induced by an adjacent supported lipid bilayer patch

被引:5
|
作者
Allerbo, Oskar [1 ]
Lundstrom, Anders [1 ]
Dimitrievski, Kristian [1 ]
机构
[1] Chalmers, Dept Appl Phys, S-41296 Gothenburg, Sweden
基金
瑞典研究理事会;
关键词
Supported lipid bilayer; Lipid vesicle; Vesicle adsorption; Vesicle rupture; Bilayer patch; Bilayer-induced vesicle rupture; Monte Carlo simulation; QUARTZ-CRYSTAL MICROBALANCE; QCM-D; ADSORPTION; EDGE; AFM; SIZE;
D O I
10.1016/j.colsurfb.2010.09.023
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Using a simple phenomenological model of a lipid bilayer and a surface, simulations were performed to study the bilayer-induced vesicle rupture probability as a vesicle adsorbs adjacently to a bilayer patch already adsorbed on the surface. The vesicle rupture probability was studied as a function of temperature, vesicle size, and surface-bilayer interaction strength. From the simulation data, estimates of the apparent activation energy for bilayer-induced vesicle rupture were calculated, both for different vesicle sizes and for different surface-bilayer interaction strengths. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:632 / 636
页数:5
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