TIMELINE The Immune Tolerance Network at 10 years: tolerance research at the bedside

被引：49

作者：

Bluestone, Jeffrey A. ^{[1
,2
]}

Auchincloss, Hugh ^{[3
]}

Nepom, Gerald T. ^{[4
]}

Rotrosen, Daniel ^{[3
]}

Clair, E. William St. ^{[5
]}

Turka, Laurence A. ^{[6
]}

机构：

[1] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[3] NIAID, Bethesda, MD 20817 USA

[4] Benaroya Res Inst, Seattle, WA 98101 USA

[5] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[6] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Transplant Inst, Boston, MA 02115 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 11期

关键词：

FACILITATED ALLERGEN BINDING; RENAL-TRANSPLANT TOLERANCE; REGULATORY T-CELLS; IN-VIVO; MARROW-TRANSPLANTATION; MULTIPLE-SCLEROSIS; RUSH IMMUNOTHERAPY; ACUTE REJECTION; COMBINED KIDNEY; CO-STIMULATION;

D O I：

10.1038/nri2869

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune tolerance-inducing therapies reprogramme immune cells to eliminate pathogenic immune responses while preserving protective immunity. The Immune Tolerance Network (ITN), sponsored by the US National Institutes of Health, was established in 1999 to evaluate new tolerance-inducing therapies and carry out mechanistic studies using a unique interactive approach in partnership with industry, academia and foundations. Ten years later, the ITN has carried out approximately 36 clinical trials and tolerance studies examining innovative tolerogenic approaches in the settings of allergy, autoimmune diseases and organ transplantation. ITN investigators have published more than 80 original research papers based on this work. This Timeline article summarizes the progress and challenges of clinical research in the ITN.

引用

页码：797 / 803

页数：7

共 45 条

[31] Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes - Results of a blinded controlled study [J].

Seyfert-Margolis, Vicki ;

Gisler, Trang D. ;

Asare, Adam L. ;

Wang, Richard S. ;

Dosch, H. Michael ;

Brooks-Worrell, Barbara ;

Eisenbarth, George S. ;

Palmer, Jerry P. ;

Greenbaum, Carla J. ;

Gitelman, Stephen E. ;

Nepom, Gerald T. ;

Bluestone, Jeffrey A. ;

Herold, Kevan C. .

DIABETES, 2006, 55 (09) :2588-2594

[32] The IgE-facilitated allergen binding (FAB) assay:: Validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses [J].

Shamji, Mohamed H. ;

Wilcock, Louisa K. ;

Wachholz, Petra A. ;

Dearman, Rebecca J. ;

Kimber, Ian ;

Wurtzen, Peter A. ;

Larche, Mark ;

Durham, Stephen R. ;

Francis, James N. .

JOURNAL OF IMMUNOLOGICAL METHODS, 2006, 317 (1-2) :71-79

[33] International trial of the edmonton protocol for islet transplantation [J].

Shapiro, A. M. James ;

Ricordi, Camillo ;

Hering, Bernhard J. ;

Auchincloss, Hugh ;

Lindblad, Robert ;

Robertson, Paul ;

Secchi, Antonio ;

Brendel, Mathias D. ;

Berney, Thierry ;

Brennan, Daniel C. ;

Cagliero, Enrico ;

Alejandro, Rodolfo ;

Ryan, Edmond A. ;

DiMercurio, Barbara ;

Morel, Philippe ;

Polonsky, Kenneth S. ;

Reems, Jo-Anna ;

Bretzel, Reinhard G. ;

Bertuzzi, Federico ;

Froud, Tatiana ;

Kandaswamy, Raja ;

Sutherland, David E. R. ;

Eisenbarth, George ;

Segal, Miriam ;

Preiksaitis, Jutta ;

Korbutt, Gregory S. ;

Barton, Franca B. ;

Viviano, Lisa ;

Seyfert-Margolis, Vicki ;

Bluestone, Jeffrey ;

Lakey, Jonathan R. T. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (13) :1318-1330

[34] Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients [J].

Sidiropoulos, PI ;

Boumpas, D .

LUPUS, 2004, 13 (05) :391-397

[35] Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis. [J].

Stone, John H. ;

Merkel, Peter A. ;

Spiera, Robert ;

Seo, Philip ;

Langford, Carol A. ;

Hoffman, Gary S. ;

Kallenberg, Cees G. M. ;

Clair, E. William St. ;

Turkiewicz, Anthony ;

Tchao, Nadia K. ;

Webber, Lisa ;

Ding, Linna ;

Sejismundo, Lourdes P. ;

Mieras, Kathleen ;

Weitzenkamp, David ;

Ikle, David ;

Seyfert-Margolis, Vicki ;

Mueller, Mark ;

Brunetta, Paul ;

Allen, Nancy B. ;

Fervenza, Fernando C. ;

Geetha, Duvuru ;

Keogh, Karina A. ;

Kissin, Eugene Y. ;

Monach, Paul A. ;

Peikert, Tobias ;

Stegeman, Coen ;

Ytterberg, Steven R. ;

Specks, Ulrich .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (03) :221-232

[36] Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction [J].

Tang, Qizhi ;

Adams, Jason Y. ;

Penaranda, Cristina ;

Melli, Kristin ;

Piaggio, Eliane ;

Sgouroudis, Evridiki ;

Piccirillo, Ciriaco A. ;

Salomon, Benoit L. ;

Bluestone, Jeffrey A. .

IMMUNITY, 2008, 28 (05) :687-697

[37]

Utset TO, 2002, J RHEUMATOL, V29, P1907

[38] THE VALUE OF IMMUNOTHERAPY WITH VENOM IN CHILDREN WITH ALLERGY TO INSECT STINGS [J].

VALENTINE, MD ;

SCHUBERTH, KC ;

KAGEYSOBOTKA, A ;

GRAFT, DF ;

KWITEROVICH, KA ;

SZKLO, M ;

LICHTENSTEIN, LM .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (23) :1601-1603

[39] CTLA4Ig treatment in patients with multiple sclerosis - An open-label, phase 1 clinical trial [J].

Viglietta, V. ;

Bourcier, K. ;

Buckle, G. J. ;

Healy, B. ;

Weiner, H. L. ;

Hafler, D. A. ;

Egorova, S. ;

Guttmann, C. R. G. ;

Rusche, J. R. ;

Khoury, S. J. .

NEUROLOGY, 2008, 71 (12) :917-924

[40]

Waubant E, 2009, MULT SCLER, V15, pS272

← 1 2 3 4 5 →