Genetics of Acquired Antibiotic Resistance Genes in Proteus spp.

被引：108

作者：

Girlich, Delphine ^{[1
,2
,3
]}

Bonnin, Remy A. ^{[1
,2
,3
]}

Dortet, Laurent ^{[1
,2
,3
]}

Naas, Thierry ^{[1
,2
,3
]}

机构：

[1] Univ Paris Saclay, Struct Dynam Funct & Express Broad Spectrum Lacta, LabEx Lermit, Fac Med, Le Kremlin Bicetre, France

[2] Associated French Natl Reference Ctr Antibiot Res, Le Kremlin Bicetre, France

[3] Univ Paris Saclay, Evolut & Ecol Resistance Antibiot Unit, Inst Pasteur, APHP, Paris, France

来源：

FRONTIERS IN MICROBIOLOGY | 2020年 / 11卷

关键词：

carbapenemase; ESBL; beta-lactamase; urinary tract infections; Proteus mirabilis; SPECTRUM-BETA-LACTAMASE; RIBOSOMAL-RNA METHYLASE; CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE; ELEMENTS CARRYING BLA(CMY-2); AMPC-TYPE CEPHALOSPORINASES; MIRABILIS CLINICAL ISOLATE; GRAM-NEGATIVE BACTERIA; KLEBSIELLA-PNEUMONIAE; ESCHERICHIA-COLI; MULTIDRUG-RESISTANT;

D O I：

10.3389/fmicb.2020.00256

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Proteus spp. are commensal Enterobacterales of the human digestive tract. At the same time, P. mirabilis is commonly involved in urinary tract infections (UTI). P. mirabilis is naturally resistant to several antibiotics including colistin and shows reduced susceptibility to imipenem. However higher levels of resistance to imipenem commonly occur in P. mirabilis isolates consecutively to the loss of porins, reduced expression of penicillin binding proteins (PBPs) PBP1a, PBP2, or acquisition of several antibiotic resistance genes, including carbapenemase genes. In addition, resistance to non-beta-lactams is also frequently reported including molecules used for treating UTI infections (e.g., fluoroquinolones, nitrofurans). Emergence and spread of multidrug resistant P. mirabilis isolates, including those producing ESBLs, AmpC cephalosporinases and carbapenemases, are being more and more frequently reported. This review covers Proteus spp. with a focus on the different genetic mechanisms involved in the acquisition of resistance genes to multiple antibiotic classes turning P. mirabilis into a dreadful pandrug resistant bacteria and resulting in difficult to treat infections.

引用

页数：21

共 182 条

[1] High Prevalence of SXT/R391-Related Integrative and Conjugative Elements Carrying blaCMY-2 in Proteus mirabilis Isolates from Gulls in the South of France [J].